TLR7 dosage polymorphism shapes interferogenesis and HIV-1 acute viremia in women

22 Jun 2020 | Publications

TLR7 dosage polymorphism shapes interferogenesis and HIV-1 acute viremia in women Pascal Azar (*), José Enrique Mejía (*), Claire Cenac (*), Arnoo Shaiykova, Ali Youness, Sophie Laffont, Asma Essat, Jacques Izopet, Caroline Passaes, Michaela Müller-Trutwin, Pierre...

A Virus Hosted in Malaria-Infected Blood Protects against T Cell-Mediated Inflammatory Diseases by Impairing DC Function in a Type I IFN-Dependent Manner

21 Apr 2020 | Publications

Viral infections: beneficial against certain inflammatory diseases? Exposure to infectious agents can affect our immune functions.  In some cases, even asymptomatic infections can improve the course of concomitant inflammatory diseases. In collaboration with A....

Long-term immunity against yellow fever in children vaccinated during infancy: a longitudinal cohort study

9 Oct 2019 | Publications

Domingo C, Fraissinet J, Ansah PO, Kelly C, Bhat N, Sow SO, Mejía JE. Yellow fever is a life-threatening viral disease endemic to tropical regions of Africa and the Americas. The vaccine against yellow fever is regarded as highly efficacious, and the World Health...

Robust Control of a Brain-Persisting Parasite through MHC I Presentation by Infected Neurons

28 Jun 2019 | Publications

Salvioni A, Belloy M, Lebourg A, Bassot E, Cantaloube-Ferrieu V, Vasseur V, Blanié S, Liblau RS, Suberbielle E, Robey EA, Blanchard N. CD8 T cells play an important role in controlling pathogens that infect the central nervous system. Toxoplasma gondii is an...

Insights into hepatitis E viral infection at the maternal-fetal unit

12 Nov 2018 | Publications

Jordi Gouilly, Qian Chen, Johan Siewiera, Géraldine Cartron, Claude Levy, Martine Dubois, Reem Al-Daccak, Jacques Izopet, Nabila Jabrane-Ferrat*, and Hicham El Costa* Centre of Pathophysiology Toulouse Purpan, INSERM U1043, CNRS UMR5282, Toulouse III University, 31024...

Hippocampal expression of a virus-derived protein impairs memory in mice

16 Apr 2018 | Publications

The analysis of the biology of neurotropic viruses, notably of their interference with cellular signaling, provides a useful tool to get further insight into the role of specific pathways in the control of behavioral functions. Here, we exploited the natural property...