MEETiCs: Metabolic, Epigenetic and Epitranscriptomic T cell interplay during Chronic inflammation and senescence.

Coordinator : Anne S. Dejean

Scientific Objectives


Metabolic remodeling is essential for T cell activation, differentiation and survival. Recent research, including our own, has highlighted the intricate interplay between metabolic reprogramming and epigenetic modifications in driving T cell functions. However, many questions remain about how changes in this interplay affect T cell fate, including exhaustion and senescence, and how they contribute to chronic inflammation, cancer, and accelerated aging. A deeper understanding of these mechanisms will pave the way for the development of tailored preventive strategies and therapies aimed to extend health span. In this context, the main objective of the MEETiCs team aims to further decipher the interplay between Metabolic adaptation and Epigenetic and Epitranscriptomic regulation of T cells during Chronic inflammation and senescence.

Our team’s projects are structured around three complementary axes, each led by a researcher responsible for securing funding, supervising postdocs, PhD students, or engineers, and benefiting from the expertise and contributions of the other researchers and team members.

Our Projects


AXE 1: Impacts of new metabolic regulators on T cell functions in chronic inflammation and cancer.

 


 

We recently demonstrated that the transcription factor Eomes is a key regulator of CD4+ T cell metabolic adaptation and epigenetic remodeling (Joulia et al, JEM, 2024). Furthermore, we recently identified a subset of Tregs co-expressing Foxp3 and Eomes that accumulate in inflamed tissues. These cells exhibit metabolic alterations, a loss of Treg identity and suppressive function, and increased plasticity (Peroceschi et al., under preparation).

We will combine animal models and patient cohorts to evaluate the contribution of Eomes+ Tregs in chronic inflammatory diseases and aging (HEC contribution). Eomes’ molecular mode of action in Tregs will be evaluated through metabolomic, transcriptomic, and epigenetic studies (VA contribution). In preclinical cancer models, we showed that Eomes controls the differentiation of the exhausted CD4+ T cell (TEX) lineage and identified their progenitors (CD4+ TPEX), a subset that exhibited self-renewal capacity and direct anti-tumoral activity (A. Agesta et al., Immunity, under review). Our ongoing project aims to decipher Eomes’ role in TPEX and TEX subset generation, maintenance and function, and to determine whether it affects the response to immunotherapy. We will explore whether Eomes modifies the metabolic dependency of T cells and examine its consequences on transcriptomic and epigenetic regulation . The clinical relevance of our findings will be evaluated in metastatic melanoma patients treated with immunotherapy.

                                                                                                                                       Coordinators: Anne S. Dejean

AXE 2: Identification of novel epigenetic and epitranscriptomic actors in CD4+ T cell functions

Multiple sclerosis (MS) is a leading cause of neurological disability affecting over 2.8 million individuals worldwide. There is currently no cure for MS as the etiology of the disease remains mostly unknown. MS is a chronic inflammatory and demyelinating disorder of the central nervous system (CNS) that results from immune dysregulation, driven by a complex interplay between genetic predisposition and environmental factors. T cells play a key role in MS, with defective regulatory functions. T cell homeostasis is controlled by a series of proteins expressed on their surface that control their activation and differentiation, including the complement regulator CD46. Alteration of the CD46 pathway is described in a number of chronic inflammatory diseases, including MS, with dysfunctional induction of Tr1 cells, secreting IL-10.

We recently demonstrated that epigenetic mechanisms, including chromatin modifiers (Adoue et al., 2019) and long non-coding RNAs (lncRNA) (Adoue et al. under preparation), play a crucial role in regulating CD4+ T cell gene expression programs. Through deep RNA-seq and refined bioinformatic analysis, we identified > 2000 novel lncRNA genes in CD4+ T subsets. Among them, we identified Lcincr as a key regulator of Treg function and Th2/Th9 cell differentiation. We will explore pathways impacted by its deletion by transcriptomic assays. As GWAS studies linked Lcincr locus to severe asthma and inflammatory bowel diseases, the function of Lcincr in CD4+ T cells will be dissected in vivo using models of asthma and IBD and confirmed in human cohorts. Furthermore, our preliminary data, together with recent literature, suggest an additional layer of complexity in CD4+ T cell differentiation driven by epitranscriptomic modifications.  However, the role of most RNA-modifying enzymes in CD4+ T cell differentiation and function remains largely unknown. Our ongoing project aim to identify novel epitranscriptomic enzymes through in vitro CRISPR/Cas9 screening, understand their molecular mechanism of action (notably using native RNA sequencing) and explore the crosstalk between epitranscriptomic and epigenetic. We have identified Mettl1, an m7G writer, as a key regulator of Th17 and Treg balance, potentially through metabolic remodeling. Given that Mettl1 belongs to a risk locus for multiple sclerosis (MS), we will evaluate the consequences of its deletion in vivo, using the EAE model and validate its function and role in CD4+ T cell metabolism in MS patients.

 

Coordinator: DR Veronique Adoue
AXE 3: Analysis of the metabolic fitness of T cells during chronic infection and aging

 
Controlled T cell immunity is a prerequisite for health. An unbalanced response may lead to autoimmune diseases if the immune system reacts too strongly, or allow tumor expansion due to inadequate immune response. Hence, the control mechanisms for accurate T cell activation and differentiation are essential to maintain a good immune homeostasis. Signaling after the engagement of receptors expressed by T cells play an important role in controlling T cell functions and polymorphism or deficiency for these signaling genes could predispose to immune-mediated diseases.

We recently found that persistent HEV infection in elderly kidney transplant patients is associated with an accumulation of terminally differentiated T cells at the acute infection phase, with these cells displaying impaired mitochondrial function and features of senescence (Gouilly et al., under preparation). Upcoming research will explore the mechanisms driving T cell senescence, focusing on the link between metabolic dysfunction and epigenetic reprogramming. By combining cellular, molecular and metabolomics approaches, we will compare immune responses across acute and chronic infection stages and evaluate whether metabolic reprogramming can restore T cell function, supporting the development of targeted therapeutic strategies for chronic infection. Furthermore, by profiling the energy metabolism of immune cells from elderly participants (INSPIRE-T cohort), we recently identified a correlation between mitochondrial dependency and IF1 expression in CD4 T cells, and improvement of functional capacity in the elderly (Jabrane-Ferrat et al., in revision, Patent #EP24315476). Using CD4-specific IF1 deficient mice and CRISPR/Cas9 edited human T cells, we will decipher the mechanisms underlying these correlations by unveiling the role of IF1 in CD4+ T cell differentiation, metabolic adaptation and function across tissues and aging. We will also examine whether targeting the IF1 pathway is an effective strategy for promoting healthy aging in mice and assess the potential of IF1 levels as a biomarker for monitoring age-related decline in the INSPIRE-T cohort.

Coordinators: DR Hicham El Costa

Other information


Publications

2024

Morandi, Elena; Adoue, Véronique; Bernard, Isabelle; Friebel, Ekaterina; Nunez, Nicolas; Aubert, Yann; Masson, Frederick; Dejean, Anne S; Becher, Burkhard; Astier, Anne; Martinet, Ludovic; Saoudi, Abdelhadi

Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions Journal Article

In: Neurol Neuroimmunol Neuroinflammation, vol. 11, no. 6, 2024.

Abstract | Links | BibTeX

Kari, Saniya; Bucciarelli, Florence; Angles, Thibault; Oster, Anne-Cecile; Cauboue, Pauline; Laviolette, Karl; Mougenot, Madeline; Morandi, Elena; Bernard, Isabelle; Pignolet, Beatrice; Bost, Chloé; Thomas, Joelle; Nogueira, Leonor; Saoudi, Abdelhadi; Liblau, Roland; Astier, Anne L

Increased levels of circulating soluble CD226 in multiple sclerosis Journal Article

In: Mult Scler, pp. 13524585241234489, 2024, ISSN: 1477-0970.

Abstract | Links | BibTeX

Joulia, Emeline; Michieletto, Michaël F.; Agesta, Arantxa; Peillex, Cindy; Girault, Virginie; Dorze, Anne-Louise Le; Peroceschi, Romain; Bucciarelli, Florence; Szelechowski, Marion; Chaubet, Adeline; Hakim, Nawad; Marrocco, Rémi; Lhuillier, Emeline; Lebeurrier, Manuel; Argüello, Rafael J.; Saoudi, Abdelhadi; Costa, Hicham El; Adoue, Veronique; Walzer, Thierry; Sarry, Jean-Emmanuel; Dejean, Anne S.

Eomes-dependent mitochondrial regulation promotes survival of pathogenic CD4+ T cells during inflammation Journal Article

In: Journal of Experimental Medicine, vol. 221, no. 2, 2024, ISSN: 0022-1007.

Links | BibTeX

2023

Liblau, Roland S; Latorre, Daniela; Kornum, Birgitte R; Dauvilliers, Yves; Mignot, Emmanuel J

The immunopathogenesis of narcolepsy type 1 Journal Article

In: Nat Rev Immunol, 2023, ISSN: 1474-1741.

Abstract | Links | BibTeX

Geeraerts, Thomas; Guilbeau-Frugier, Céline; Garcia, Cédric; Memier, Vincent; Raposo, Nicolas; Bonneville, Fabrice; Gales, Céline; Darcourt, Jean; Voisin, Sophie; Ribes, Agnès; Piel-Julian, Marie; Bounes, Fanny; Albucher, Jean François; Roux, Franck-Emmanuel; Izopet, Jacques; Telmon, Norbert; Olivot, Jean Marc; Sié, Pierre; Bauer, Jan; Payrastre, Bernard; Liblau, Roland S

Immunohistologic Features of Cerebral Venous Thrombosis Due to Vaccine-Induced Immune Thrombotic Thrombocytopenia Journal Article

In: Neurol Neuroimmunol Neuroinflamm, vol. 10, no. 4, 2023, ISSN: 2332-7812.

Abstract | Links | BibTeX

Gonzalez-Fierro, Carmen; Fonte, Coralie; Dufourd, Eloïse; Cazaentre, Vincent; Aydin, Sidar; Engelhardt, Britta; Caspi, Rachel R; Xu, Biying; Martin-Blondel, Guillaume; Spicer, Julie A; Trapani, Joseph A; Bauer, Jan; Liblau, Roland S; Bost, Chloé

Effects of a Small-Molecule Perforin Inhibitor in a Mouse Model of CD8 T Cell-Mediated Neuroinflammation Journal Article

In: Neurol Neuroimmunol Neuroinflamm, vol. 10, no. 4, 2023, ISSN: 2332-7812.

Abstract | Links | BibTeX

Seifinejad, Ali; Ramosaj, Mergim; Shan, Ling; Li, Sha; Possovre, Marie-Laure; Pfister, Corinne; Fronczek, Rolf; Garrett-Sinha, Lee A; Frieser, David; Honda, Makoto; Arribat, Yoan; Grepper, Dogan; Amati, Francesca; Picot, Marie; Agnoletto, Andrea; Iseli, Christian; Chartrel, Nicolas; Liblau, Roland; Lammers, Gert J; Vassalli, Anne; Tafti, Mehdi

Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy Journal Article

In: Proc Natl Acad Sci U S A, vol. 120, no. 19, pp. e2220911120, 2023, ISSN: 1091-6490.

Abstract | Links | BibTeX

Aydin, Sidar; Pareja, Javier; Schallenberg, Vivianne M; Klopstein, Armelle; Gruber, Thomas; Page, Nicolas; Bouillet, Elisa; Blanchard, Nicolas; Liblau, Roland; Körbelin, Jakob; Schwaninger, Markus; Johnson, Aaron J; Schenk, Mirjam; Deutsch, Urban; Merkler, Doron; Engelhardt, Britta

Antigen recognition detains CD8 T cells at the blood-brain barrier and contributes to its breakdown Journal Article

In: Nat Commun, vol. 14, no. 1, pp. 3106, 2023, ISSN: 2041-1723.

Abstract | Links | BibTeX

Martin-Blondel, Guillaume; Marcelin, Anne-Geneviève; Soulié, Cathia; Kaisaridi, Sofia; Lusivika-Nzinga, Clovis; Zafilaza, Karen; Dorival, Céline; Nailler, Laura; Boston, Anaïs; Ronchetti, Anne-Marie; Melenotte, Cléa; Cabié, André; Choquet, Christophe; Trinh-Duc, Albert; Lacombe, Karine; Gaube, Géraldine; Coustillères, François; Pourcher, Valérie; Martellosio, Jean-Philippe; Peiffer-Smadja, Nathan; Chauveau, Marie; Housset, Pierre; Piroth, Lionel; Devaux, Mathilde; Pialoux, Gilles; Martin, Aurélie; Dubee, Vincent; Frey, Jérôme; Bot, Audrey Le; Cazanave, Charles; Petua, Philippe; Liblau, Roland; Carrat, Fabrice; Yordanov, Youri

Time to negative PCR conversion amongst high-risk patients with mild-to-moderate Omicron BA.1 and BA.2 COVID-19 treated with sotrovimab or nirmatrelvir Journal Article

In: Clin Microbiol Infect, vol. 29, no. 4, pp. 543.e5–543.e9, 2023, ISSN: 1469-0691.

Abstract | Links | BibTeX

Texier, Baptiste; Prime, Morgane; Atamena, Djamaa; Belenguer, Pascale; Szelechowski, Marion

Mortalin/Hspa9 involvement and therapeutic perspective in Parkinson's disease Journal Article

In: Neural Regen Res, vol. 18, no. 2, pp. 293–298, 2023, ISSN: 1673-5374.

Abstract | Links | BibTeX

Faure, Fabrice; Yshii, Lidia; Renno, Toufic; Coste, Isabelle; Joubert, Bastien; Desestret, Virginie; Liblau, Roland; Honnorat, Jérôme

A Pilot Study to Develop Paraneoplastic Cerebellar Degeneration Mouse Model Journal Article

In: Cerebellum, 2023, ISSN: 1473-4230.

Abstract | Links | BibTeX

Astier, Anne L; Kofler, David M

Editorial: Dysregulation of Th17 and Treg cells in autoimmune diseases Journal Article

In: Front Immunol, vol. 14, pp. 1151836, 2023, ISSN: 1664-3224.

Links | BibTeX

de Sèze, Jérôme; Maillart, Elisabeth; Gueguen, Antoine; Laplaud, David A; Michel, Laure; Thouvenot, Eric; Zephir, Hélène; Zimmer, Luc; Biotti, Damien; Liblau, Roland

Anti-CD20 therapies in multiple sclerosis: From pathology to the clinic Journal Article

In: Front Immunol, vol. 14, pp. 1004795, 2023, ISSN: 1664-3224.

Abstract | Links | BibTeX

Ayoub, Ikram; Dauvilliers, Yves; Barateau, Lucie; Vermeulen, Thaïs; Mouton-Barbosa, Emmanuelle; Marcellin, Marlène; Gonzalez-de-Peredo, Anne; Gross, Catharina C; Saoudi, Abdelhadi; Liblau, Roland

Cerebrospinal fluid proteomics in recent-onset Narcolepsy type 1 reveals activation of the complement system Journal Article

In: Front Immunol, vol. 14, pp. 1108682, 2023, ISSN: 1664-3224.

Abstract | Links | BibTeX

2022

Schneider-Hohendorf, Tilman; Gerdes, Lisa Ann; Pignolet, Béatrice; Gittelman, Rachel; Ostkamp, Patrick; Rubelt, Florian; Raposo, Catarina; Tackenberg, Björn; Riepenhausen, Marianne; Janoschka, Claudia; Wünsch, Christian; Bucciarelli, Florence; Flierl-Hecht, Andrea; Beltrán, Eduardo; Kümpfel, Tania; Anslinger, Katja; Gross, Catharina C; Chapman, Heidi; Kaplan, Ian; Brassat, David; Wekerle, Hartmut; Kerschensteiner, Martin; Klotz, Luisa; Lünemann, Jan D; Hohlfeld, Reinhard; Liblau, Roland; Wiendl, Heinz; Schwab, Nicholas

Broader Epstein-Barr virus-specific T cell receptor repertoire in patients with multiple sclerosis Journal Article

In: J Exp Med, vol. 219, no. 11, 2022, ISSN: 1540-9538.

Abstract | Links | BibTeX

Martin-Blondel, Guillaume; Marcelin, Anne-Genevieve; Soulié, Cathia; Kaisaridi, Sofia; Lusivika-Nzinga, Clovis; Dorival, Céline; Nailler, Laura; Boston, Anaïs; Melenotte, Cléa; Cabié, André; Choquet, Christophe; Coustillères, François; Martellosio, Jean-Philippe; Gaube, Géraldine; Trinh-Duc, Albert; Ronchetti, Anne-Marie; Pourcher, Valerie; Chauveau, Marie; Lacombe, Karine; Peiffer-Smadja, Nathan; Housset, Pierre; Perrot, Aurore; Pialoux, Gilles; Martin, Aurélie; Dubee, Vincent; Devaux, Mathilde; Frey, Jérôme; Cazanave, Charles; Liblau, Roland; Carrat, Fabrice; Yordanov, Youri

Sotrovimab to prevent severe COVID-19 in high-risk patients infected with Omicron BA.2 Miscellaneous

2022, ISSN: 1532-2742.

Links | BibTeX

Chiu, Isaac M; Liblau, Roland

Editorial overview: Special section neuroimmunology: Neuroimmune interactions in health and disease Miscellaneous

2022, ISSN: 1879-0372.

Links | BibTeX

Merkler, Doron; Vincenti, Ilena; Masson, Frederick; Liblau, Roland S

Tissue-resident CD8 T cells in central nervous system inflammatory diseases: present at the crime scene and …guilty Journal Article

In: Curr Opin Immunol, vol. 77, pp. 102211, 2022, ISSN: 1879-0372.

Abstract | Links | BibTeX

Bernard-Valnet, Raphaël; Frieser, David; Nguyen, Xuan Hung; Khajavi, Leila; Quériault, Clémence; Arthaud, Sébastien; Melzi, Silvia; Fusade-Boyer, Maxime; Masson, Frederick; Zytnicki, Matthias; Saoudi, Abdelhadi; Dauvilliers, Yves; Peyron, Christelle; Bauer, Jan; Liblau, Roland S

Influenza vaccination induces autoimmunity against orexinergic neurons in a mouse model for narcolepsy Journal Article

In: Brain, vol. 145, no. 6, pp. 2018–2030, 2022, ISSN: 1460-2156.

Abstract | Links | BibTeX

Bernard-Valnet, Raphaël; Frieser, David; Nguyen, Xuan Hung; Khajavi, Leila; Quériault, Clémence; Arthaud, Sébastien; Melzi, Silvia; Fusade-Boyer, Maxime; Masson, Frederick; Zytnicki, Matthias; Saoudi, Abdelhadi; Dauvilliers, Yves; Peyron, Christelle; Bauer, Jan; Liblau, Roland S

Influenza vaccination induces autoimmunity against orexinergic neurons in a mouse model for narcolepsy Journal Article

In: Brain, vol. 145, no. 6, pp. 2018–2030, 2022, ISSN: 1460-2156.

Abstract | Links | BibTeX

Gaudenzio, Nicolas; Liblau, Roland S

Immune cells impede repair of old neurons Journal Article

In: Science, vol. 376, no. 6594, pp. 694–695, 2022, ISSN: 1095-9203.

Abstract | Links | BibTeX

Frieser, David; Pignata, Aurora; Khajavi, Leila; Shlesinger, Danielle; Gonzalez-Fierro, Carmen; Nguyen, Xuan-Hung; Yermanos, Alexander; Merkler, Doron; Höftberger, Romana; Desestret, Virginie; Mair, Katharina M; Bauer, Jan; Masson, Frederick; Liblau, Roland S

Tissue-resident CD8 T cells drive compartmentalized and chronic autoimmune damage against CNS neurons Journal Article

In: Sci Transl Med, vol. 14, no. 640, pp. eabl6157, 2022, ISSN: 1946-6242.

Abstract | Links | BibTeX

Hohlfeld, Reinhard; Liblau, Roland S

Toward identification of personalized immunological profiles in multiple sclerosis Journal Article

In: Sci Adv, vol. 8, no. 17, pp. eabq4849, 2022, ISSN: 2375-2548.

Abstract | Links | BibTeX

Kreutmair, Stefanie; Unger, Susanne; Núñez, Nicolás Gonzalo; Ingelfinger, Florian; Alberti, Chiara; Feo, Donatella De; Krishnarajah, Sinduya; Kauffmann, Manuel; Friebel, Ekaterina; Babaei, Sepideh; Gaborit, Benjamin; Lutz, Mirjam; Jurado, Nicole Puertas; Malek, Nisar P; Goepel, Siri; Rosenberger, Peter; Häberle, Helene A; Ayoub, Ikram; Al-Hajj, Sally; Nilsson, Jakob; Claassen, Manfred; Liblau, Roland; Martin-Blondel, Guillaume; Bitzer, Michael; Roquilly, Antoine; Becher, Burkhard

Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia Miscellaneous

2022, ISSN: 1097-4180.

Links | BibTeX

Galoppin, Manon; Kari, Saniya; Soldati, Sasha; Pal, Arindam; Rival, Manon; Engelhardt, Britta; Astier, Anne; Thouvenot, Eric

Full spectrum of vitamin D immunomodulation in multiple sclerosis: mechanisms and therapeutic implications Journal Article

In: Brain Commun, vol. 4, no. 4, pp. fcac171, 2022, ISSN: 2632-1297.

Abstract | Links | BibTeX

Yang, Cui; Blaize, Gaëtan; Marrocco, Rémi; Rouquié, Nelly; Bories, Cyrielle; Gador, Mylène; Mélique, Suzanne; Joulia, Emeline; Benamar, Mehdi; Dejean, Anne S.; Daniels-Treffandier, Hélène; Love, Paul E.; Fazilleau, Nicolas; Saoudi, Abdelhadi; Lesourne, Renaud

THEMIS enhances the magnitude of normal and neuroinflammatory type 1 immune responses by promoting TCR-independent signals Journal Article

In: Science Signaling, vol. 15, no. 742, pp. eabl5343, 2022, (Publisher: American Association for the Advancement of Science).

Links | BibTeX

2021

Tuzlak, Selma; Dejean, Anne S; Iannacone, Matteo; Quintana, Francisco J; Waisman, Ari; Ginhoux, Florent; Korn, Thomas; Becher, Burkhard

Repositioning T cell polarization from single cytokines to complex help Journal Article

In: Nat Immunol, vol. 22, no. 10, pp. 1210–1217, 2021, ISSN: 1529-2916.

Abstract | Links | BibTeX

Wiendl, Heinz; Gross, Catharina C; Bauer, Jan; Merkler, Doron; Prat, Alexandre; Liblau, Roland

Fundamental mechanistic insights from rare but paradigmatic neuroimmunological diseases Journal Article

In: Nat Rev Neurol, vol. 17, no. 7, pp. 433–447, 2021, ISSN: 1759-4766.

Abstract | Links | BibTeX

Karmakar, Utsa; Chu, Julia Y; Sundaram, Kruthika; Astier, Anne L; Garside, Hannah; Hansen, Carsten G; Dransfield, Ian; Vermeren, Sonja

Immune complex-induced apoptosis and concurrent immune complex clearance are anti-inflammatory neutrophil functions Journal Article

In: Cell Death Dis, vol. 12, no. 4, pp. 296, 2021, ISSN: 2041-4889.

Abstract | Links | BibTeX

Rousset, S.; Lafaurie, M.; Guet-Revillet, H.; Protin, C.; Le Grusse, J.; Derumeaux, H.; Gandia, P.; Nourhashemi, F.; Sailler, L.; Sommet, A.; Delobel, P.; Martin-Blondel, G.

Safety of Pyrazinamide for the Treatment of Tuberculosis in Older Patients Over 75 Years of Age: A Retrospective Monocentric Cohort Study Journal Article

In: Drugs Aging, vol. 38, no. 1, pp. 43-52, 2021, ISSN: 1179-1969 (Electronic) 1170-229X (Linking).

Links | BibTeX

Guyonnet, S; Rolland, Y; Takeda, C; Ousset, P-J; Ader, I; Davezac, N; Dray, C; Fazilleau, N; Gourdy, P; Liblau, R; Parini, A; Payoux, P; Pénicaud, L; Rampon, C; Valet, P; Vergnolle, N; Andrieu, S; de Souto Barreto, P; Casteilla, L; Vellas, B

The INSPIRE Bio-Resource Research Platform for Healthy Aging and Geroscience: Focus on the Human Translational Research Cohort (The INSPIRE-T Cohort) Journal Article

In: J Frailty Aging, vol. 10, no. 2, pp. 110–120, 2021, ISSN: 2260-1341.

Abstract | Links | BibTeX

de Souto Barreto, P; Guyonnet, S; Ader, I; Andrieu, S; Casteilla, L; Davezac, N; Dray, C; Fazilleau, N; Gourdy, P; Liblau, R; Parini, A; Payoux, P; Pénicaud, L; Rampon, C; Rolland, Y; Valet, P; Vergnolle, N; Vellas, B

The INSPIRE Research Initiative: A Program for GeroScience and Healthy Aging Research Going from Animal Models to Humans and the Healthcare System Journal Article

In: J Frailty Aging, vol. 10, no. 2, pp. 86–93, 2021, ISSN: 2260-1341.

Abstract | Links | BibTeX

2020

Yshii, L.; Bost, C.; Liblau, R.

Immunological Bases of Paraneoplastic Cerebellar Degeneration and Therapeutic Implications Journal Article

In: Front Immunol, vol. 11, pp. 991, 2020, ISSN: 1664-3224 (Electronic) 1664-3224 (Linking).

Links | BibTeX

Pavlovic, M.; Gross, C.; Chili, C.; Secher, T.; Treiner, E.

MAIT Cells Display a Specific Response to Type 1 IFN Underlying the Adjuvant Effect of TLR7/8 Ligands Journal Article

In: Front Immunol, vol. 11, pp. 2097, 2020, ISSN: 1664-3224 (Electronic) 1664-3224 (Linking).

Links | BibTeX

Malviya, M.; Saoudi, A.; Bauer, J.; Fillatreau, S.; Liblau, R.

Treatment of experimental autoimmune encephalomyelitis with engineered bi-specific Foxp3+ regulatory CD4+ T cells Journal Article

In: J Autoimmun, vol. 108, pp. 102401, 2020, ISSN: 1095-9157 (Electronic) 0896-8411 (Linking).

Links | BibTeX

Killick, J.; Hay, J.; Morandi, E.; Vermeren, S.; Kari, S.; Angles, T.; Williams, A.; Damoiseaux, J.; Astier, A. L.

Vitamin D/CD46 Crosstalk in Human T Cells in Multiple Sclerosis Journal Article

In: Front Immunol, vol. 11, pp. 598727, 2020, ISSN: 1664-3224 (Electronic) 1664-3224 (Linking).

Links | BibTeX

Kamar, N.; Esposito, L.; Hebral, A. L.; Guitard, J.; Del Bello, A.

Specific organization for in-hospital belatacept infusion to avoid nosocomial transmission during the SARS-CoV-2 pandemic Journal Article

In: Am J Transplant, vol. 20, no. 10, pp. 2962-2963, 2020, ISSN: 1600-6143 (Electronic) 1600-6135 (Linking).

Links | BibTeX

Del Bello, A.; Kamar, N.; Treiner, E.

T cell reconstitution after lymphocyte depletion features a different pattern of inhibitory receptor expression in ABO- versus HLA-incompatible kidney transplant recipients Journal Article

In: Clin Exp Immunol, vol. 200, no. 1, pp. 89-104, 2020, ISSN: 1365-2249 (Electronic) 0009-9104 (Linking).

Links | BibTeX

Cohen, M.; Mondot, L.; Bucciarelli, F.; Pignolet, B.; Laplaud, D. A.; Wiertlewski, S.; Brochet, B.; Ruet, A.; Defer, G.; Derache, N.; Vermersch, P.; Zephir, H.; Debouverie, M.; Mathey, G.; Berger, E.; Cappe, C.; Labauge, P.; Carra, C.; De Seze, J.; Bigaut, K.; Brassat, D.; Lebrun-Frenay, C.

BEST-MS: A prospective head-to-head comparative study of natalizumab and fingolimod in active relapsing MS Journal Article

In: Mult Scler, pp. 1352458520969145, 2020, ISSN: 1477-0970 (Electronic) 1352-4585 (Linking).

Links | BibTeX

2019

Eyoh, Enwono; McCallum, Patrick; Killick, Justin; Amanfo, Seth; Mutapi, Francisca; Astier, Anne L

The anthelmintic drug praziquantel promotes human Tr1 differentiation Journal Article

In: Immunol Cell Biol, vol. 97, no. 5, pp. 512–518, 2019, ISSN: 1440-1711.

Abstract | Links | BibTeX

Rousset, S.; Treiner, E.; Moulis, G.; Pugnet, G.; Astudillo, L.; Paricaud, K.; Puissant-Lubrano, B.; Arlet, P.; Blancher, A.; Sailler, L.

High rate of indeterminate results of the QuantiFERON-TB Gold in-tube test, third generation, in patients with systemic vasculitis Journal Article

In: Rheumatology (Oxford), 2019, ISSN: 1462-0332 (Electronic) 1462-0324 (Linking).

Links | BibTeX

Aron Badin, R.; Bugi, A.; Williams, S.; Vadori, M.; Michael, M.; Jan, C.; Nassi, A.; Lecourtois, S.; Blancher, A.; Cozzi, E.; Hantraye, P.; Perrier, A. L.

MHC matching fails to prevent long-term rejection of iPSC-derived neurons in non-human primates Journal Article

In: Nat Commun, vol. 10, no. 1, pp. 4357, 2019, ISSN: 2041-1723 (Electronic) 2041-1723 (Linking).

Links | BibTeX

Bassetti, C. L. A.; Adamantidis, A.; Burdakov, D.; Han, F.; Gay, S.; Kallweit, U.; Khatami, R.; Koning, F.; Kornum, B. R.; Lammers, G. J.; Liblau, R. S.; Luppi, P. H.; Mayer, G.; Pollmacher, T.; Sakurai, T.; Sallusto, F.; Scammell, T. E.; Tafti, M.; Dauvilliers, Y.

Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment Journal Article

In: Nat Rev Neurol, vol. 15, no. 9, pp. 519-539, 2019, ISSN: 1759-4766 (Electronic) 1759-4758 (Linking).

Links | BibTeX

Beltran, E.; Nguyen, X. H.; Queriault, C.; Barateau, L.; Dauvilliers, Y.; Dornmair, K.; Liblau, R. S.

Shared T cell receptor chains in blood memory CD4(+) T cells of narcolepsy type 1 patients Journal Article

In: J Autoimmun, vol. 100, pp. 1-6, 2019, ISSN: 1095-9157 (Electronic) 0896-8411 (Linking).

Links | BibTeX

Dejean, A. S.; Joulia, E.; Walzer, T.

The role of Eomes in human CD4 T cell differentiation: A question of context Journal Article

In: Eur J Immunol, vol. 49, no. 1, pp. 38-41, 2019, ISSN: 1521-4141 (Electronic) 0014-2980 (Linking).

Links | BibTeX

Yshii, L.; Pignolet, B.; Maure, E.; Pierau, M.; Brunner-Weinzierl, M.; Hartley, O.; Bauer, J.; Liblau, R.

IFN-gamma is a therapeutic target in paraneoplastic cerebellar degeneration Journal Article

In: JCI Insight, vol. 4, no. 7, 2019, ISSN: 2379-3708 (Electronic) 2379-3708 (Linking).

Links | BibTeX

Giner-Delgado, C.; Villatoro, S.; Lerga-Jaso, J.; Gaya-Vidal, M.; Oliva, M.; Castellano, D.; Pantano, L.; Bitarello, B. D.; Izquierdo, D.; Noguera, I.; Olalde, I.; Delprat, A.; Blancher, A.; Lalueza-Fox, C.; Esko, T.; O'Reilly, P. F.; Andres, A. M.; Ferretti, L.; Puig, M.; Caceres, M.

Evolutionary and functional impact of common polymorphic inversions in the human genome Journal Article

In: Nat Commun, vol. 10, no. 1, pp. 4222, 2019, ISSN: 2041-1723 (Electronic) 2041-1723 (Linking).

Links | BibTeX

Walter, O.; Treiner, E.; Bonneville, F.; Mengelle, C.; Vergez, F.; Lerebours, F.; Delobel, P.; Liblau, R.; Martin-Blondel, G.; Immune Checkpoint Inhibitors in, P. M. L. Study Group

Treatment of Progressive Multifocal Leukoencephalopathy with Nivolumab Journal Article

In: N Engl J Med, vol. 380, no. 17, pp. 1674-1676, 2019, ISSN: 1533-4406 (Electronic) 0028-4793 (Linking).

Links | BibTeX

Klotz, L.; Eschborn, M.; Lindner, M.; Liebmann, M.; Herold, M.; Janoschka, C.; Torres Garrido, B.; Schulte-Mecklenbeck, A.; Gross, C. C.; Breuer, J.; Hundehege, P.; Posevitz, V.; Pignolet, B.; Nebel, G.; Glander, S.; Freise, N.; Austermann, J.; Wirth, T.; Campbell, G. R.; Schneider-Hohendorf, T.; Eveslage, M.; Brassat, D.; Schwab, N.; Loser, K.; Roth, J.; Busch, K. B.; Stoll, M.; Mahad, D. J.; Meuth, S. G.; Turner, T.; Bar-Or, A.; Wiendl, H.

Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects Journal Article

In: Sci Transl Med, vol. 11, no. 490, 2019, ISSN: 1946-6242 (Electronic) 1946-6234 (Linking).

Links | BibTeX

Schwab, N.; Schneider-Hohendorf, T.; Pignolet, B.; Bucciarelli, F.; Scandella, L.; Ciron, J.; Biotti, D.; Lebrun-Frenay, C.; Mathey, G.; Clavelou, P.; Pelletier, J.; Ostkamp, P.; Meinl, I.; Windhagen, S.; Klotz, L.; Gross, C. C.; Meuth, S. G.; Deisenhammer, F.; Brassat, D.; Wiendl, H.; Best, M. S. Study Group

Prospective validation of the PML risk biomarker l-selectin and influence of natalizumab extended intervals Journal Article

In: Neurology, vol. 93, no. 12, pp. 550-554, 2019, ISSN: 1526-632X (Electronic) 0028-3878 (Linking).

Links | BibTeX

Salvioni, A.; Belloy, M.; Lebourg, A.; Bassot, E.; Cantaloube-Ferrieu, V.; Vasseur, V.; Blanie, S.; Liblau, R. S.; Suberbielle, E.; Robey, E. A.; Blanchard, N.

Robust Control of a Brain-Persisting Parasite through MHC I Presentation by Infected Neurons Journal Article

In: Cell Rep, vol. 27, no. 11, pp. 3254-3268 e8, 2019, ISSN: 2211-1247 (Electronic).

Links | BibTeX

2018

Melliez, H.; Mary-Krause, M.; Bocket, L.; Guiguet, M.; Abgrall, S.; De Truchis, P.; Katlama, C.; Martin-Blondel, G.; Henn, A.; Revest, M.; Robineau, O.; Khuong-Josses, M. A.; Canestri, A.; De Castro, N.; Joly, V.; Mokhtari, S.; Risso, K.; Gasnault, J.; Costagliola, D.; French Hospital Database on, H. I. V.

Risk of Progressive Multifocal Leukoencephalopathy in the Combination Antiretroviral Therapy Era in the French Hospital Database on Human Immunodeficiency Virus (ANRS-C4) Journal Article

In: Clin Infect Dis, vol. 67, no. 2, pp. 275-282, 2018, ISSN: 1537-6591 (Electronic) 1058-4838 (Linking).

Links | BibTeX

Eissmann, M. F.; Dijkstra, C.; Wouters, M. A.; Baloyan, D.; Mouradov, D.; Nguyen, P. M.; Davalos-Salas, M.; Putoczki, T. L.; Sieber, O. M.; Mariadason, J. M.; Ernst, M.; Masson, F.

Interleukin 33 Signaling Restrains Sporadic Colon Cancer in an Interferon-gamma-Dependent Manner Journal Article

In: Cancer Immunol Res, vol. 6, no. 4, pp. 409-421, 2018, ISSN: 2326-6074 (Electronic) 2326-6066 (Linking).

Links | BibTeX

Januel, E.; Martin-Blondel, G.; Lamirel, C.; Picard, H.; Pialoux, G.; Katlama, C.; Cochereau, I.; Lescure, F. X.; Moulignier, A.

Do CCR5 antagonists improve the overall survival of patients with AIDS-related progressive multifocal leucoencephalopathy? Journal Article

In: J Neurol Neurosurg Psychiatry, vol. 89, no. 10, pp. 1125-1126, 2018, ISSN: 1468-330X (Electronic) 0022-3050 (Linking).

Links | BibTeX

Mansuy, J. M.; Lhomme, S.; Cazabat, M.; Pasquier, C.; Martin-Blondel, G.; Izopet, J.

Detection of Zika, dengue and chikungunya viruses using single-reaction multiplex real-time RT-PCR Journal Article

In: Diagn Microbiol Infect Dis, vol. 92, no. 4, pp. 284-287, 2018, ISSN: 1879-0070 (Electronic) 0732-8893 (Linking).

Links | BibTeX

Montalban, X.; Gold, R.; Thompson, A. J.; Otero-Romero, S.; Amato, M. P.; Chandraratna, D.; Clanet, M.; Comi, G.; Derfuss, T.; Fazekas, F.; Hartung, H. P.; Havrdova, E.; Hemmer, B.; Kappos, L.; Liblau, R.; Lubetzki, C.; Marcus, E.; Miller, D. H.; Olsson, T.; Pilling, S.; Selmaj, K.; Siva, A.; Sorensen, P. S.; Sormani, M. P.; Thalheim, C.; Wiendl, H.; Zipp, F.

ECTRIMS/EAN Guideline on the pharmacological treatment of people with multiple sclerosis Journal Article

In: Mult Scler, vol. 24, no. 2, pp. 96-120, 2018, ISSN: 1477-0970 (Electronic) 1352-4585 (Linking).

Links | BibTeX

Tugues, S.; Amorim, A.; Spath, S.; Martin-Blondel, G.; Schreiner, B.; De Feo, D.; Lutz, M.; Guscetti, F.; Apostolova, P.; Haftmann, C.; Hasselblatt, P.; Nunez, N. G.; Hottiger, M. O.; van den Broek, M.; Manz, M. G.; Zeiser, R.; Becher, B.

Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF-licensed myeloid cells Journal Article

In: Sci Transl Med, vol. 10, no. 469, 2018, ISSN: 1946-6242 (Electronic) 1946-6234 (Linking).

Links | BibTeX

Liblau, R. S.

Put to sleep by immune cells Journal Article

In: Nature, vol. 562, no. 7725, pp. 46-48, 2018, ISSN: 1476-4687 (Electronic) 0028-0836 (Linking).

Links | BibTeX

Gaud, G.; Roncagalli, R.; Chaoui, K.; Bernard, I.; Familiades, J.; Colacios, C.; Kassem, S.; Monsarrat, B.; Burlet-Schiltz, O.; de Peredo, A. G.; Malissen, B.; Saoudi, A.

The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4(+) T cells Journal Article

In: Sci Signal, vol. 11, no. 538, 2018, ISSN: 1937-9145 (Electronic) 1945-0877 (Linking).

Links | BibTeX

2017

Yshii, L. M.; Hohlfeld, R.; Liblau, R. S.

Inflammatory CNS disease caused by immune checkpoint inhibitors: status and perspectives Journal Article

In: Nat Rev Neurol, vol. 13, no. 12, pp. 755-763, 2017, ISSN: 1759-4766 (Electronic) 1759-4758 (Linking).

Links | BibTeX

Yu, C.; Fitzpatrick, A.; Cong, D.; Yao, C.; Yoo, J.; Turnbull, A.; Schwarze, J.; Norval, M.; Howie, S. E. M.; Weller, R. B.; Astier, A. L.

Nitric oxide induces human CLA+CD25+Foxp3+ regulatory T cells with skin-homing potential Journal Article

In: J Allergy Clin Immunol, 2017, ISSN: 1097-6825 (Electronic) 0091-6749 (Linking).

Links | BibTeX

Yshii, L. M.; Hohlfeld, R.; Liblau, R. S.

Inflammatory CNS disease caused by immune checkpoint inhibitors: status and perspectives Journal Article

In: Nat Rev Neurol, vol. 13, no. 12, pp. 755-763, 2017, ISSN: 1759-4766 (Electronic) 1759-4758 (Linking).

Links | BibTeX

Ni Choileain, S.; Hay, J.; Thomas, J.; Williams, A.; Vermeren, M. M.; Benezech, C.; Gomez-Salazar, M.; Hugues, O. R.; Vermeren, S.; Howie, S. E. M.; Dransfield, I.; Astier, A. L.

TCR-stimulated changes in cell surface CD46 expression generate type 1 regulatory T cells Journal Article

In: Sci Signal, vol. 10, no. 502, 2017, ISSN: 1937-9145 (Electronic) 1945-0877 (Linking).

Links | BibTeX

Fissolo, N.; Pignolet, B.; Matute-Blanch, C.; Trivino, J. C.; Miro, B.; Mota, M.; Perez-Hoyos, S.; Sanchez, A.; Vermersch, P.; Ruet, A.; de Seze, J.; Labauge, P.; Vukusic, S.; Papeix, C.; Almoyna, L.; Tourbah, A.; Clavelou, P.; Moreau, T.; Pelletier, J.; Lebrun-Frenay, C.; Montalban, X.; Brassat, D.; Comabella, M.; Biomarkers,; Response to Natalizumab for Multiple Sclerosis Treatment, Best EScalation Treatment in Multiple Sclerosis; the Societe Francophone de la Sclerose En Plaques, Network

Matrix metalloproteinase 9 is decreased in natalizumab-treated multiple sclerosis patients at risk for progressive multifocal leukoencephalopathy Journal Article

In: Ann Neurol, vol. 82, no. 2, pp. 186-195, 2017, ISSN: 1531-8249 (Electronic) 0364-5134 (Linking).

Links | BibTeX

Yu, C.; Fitzpatrick, A.; Cong, D.; Yao, C.; Yoo, J.; Turnbull, A.; Schwarze, J.; Norval, M.; Howie, S. E. M.; Weller, R. B.; Astier, A. L.

Nitric oxide induces human CLA+CD25+Foxp3+ regulatory T cells with skin-homing potential Journal Article

In: J Allergy Clin Immunol, 2017, ISSN: 1097-6825 (Electronic) 0091-6749 (Linking).

Links | BibTeX

Gebauer, C.; Pignolet, B.; Yshii, L.; Maure, E.; Bauer, J.; Liblau, R.

CD4+ and CD8+ T cells are both needed to induce paraneoplastic neurological disease in a mouse model Journal Article

In: Oncoimmunology, vol. 6, no. 2, pp. e1260212, 2017, ISSN: 2162-4011 (Print) 2162-4011 (Linking).

Links | BibTeX

Duguet, F.; Locard-Paulet, M.; Marcellin, M.; Chaoui, K.; Bernard, I.; Andreoletti, O.; Lesourne, R.; Burlet-Schiltz, O.; Gonzalez de Peredo, A.; Saoudi, A.

Proteomic Analysis of Regulatory T Cells Reveals the Importance of Themis1 in the Control of Their Suppressive Function Journal Article

In: Mol Cell Proteomics, vol. 16, no. 8, pp. 1416-1432, 2017, ISSN: 1535-9484 (Electronic) 1535-9476 (Linking).

Links | BibTeX

2016

Ramadan, A.; Lucca, L. E.; Carrie, N.; Desbois, S.; Axisa, P. P.; Hayder, M.; Bauer, J.; Liblau, R. S.; Mars, L. T.

In situ expansion of T cells that recognize distinct self-antigens sustains autoimmunity in the CNS Journal Article

In: Brain, vol. 139, no. Pt 5, pp. 1433-46, 2016, ISSN: 1460-2156 (Electronic) 0006-8950 (Linking).

Links | BibTeX

Kassem, S.; Gaud, G.; Bernard, I.; Benamar, M.; Dejean, A. S.; Liblau, R.; Fournie, G. J.; Colacios, C.; Malissen, B.; Saoudi, A.

A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation Journal Article

In: PLoS Genet, vol. 12, no. 7, pp. e1006185, 2016, ISSN: 1553-7404 (Electronic) 1553-7390 (Linking).

Links | BibTeX

Martin-Blondel, G.; Brassat, D.; Bauer, J.; Lassmann, H.; Liblau, R. S.

CCR5 blockade for neuroinflammatory diseases--beyond control of HIV Journal Article

In: Nat Rev Neurol, vol. 12, no. 2, pp. 95-105, 2016, ISSN: 1759-4766 (Electronic) 1759-4758 (Linking).

Links | BibTeX

Pignolet, B.; Schwab, N.; Schneider-Hohendorf, T.; Bucciarelli, F.; Biotti, D.; Averseng-Peaureaux, D.; Outteryck, O.; Ongagna, J. C.; de Seze, J.; Brochet, B.; Ouallet, J. C.; Debouverie, M.; Pittion, S.; Defer, G.; Derache, N.; Hautecoeur, P.; Tourbah, A.; Labauge, P.; Castelnovo, G.; Clavelou, P.; Berger, E.; Pelletier, J.; Rico, A.; Zephir, H.; Laplaud, D.; Wiertlewski, S.; Camu, W.; Thouvenot, E.; Casez, O.; Moreau, T.; Fromont, A.; Vukusic, S.; Papeix, C.; Vermersch, P.; Comabella, M.; Lebrun-Frenay, C.; Wiendl, H.; Brassat, D.; Bionat, Sfsep; networks, Best-Ms

CD62L test at 2 years of natalizumab predicts progressive multifocal leukoencephalopathy Journal Article

In: Neurology, vol. 87, no. 23, pp. 2491-2494, 2016, ISSN: 1526-632X (Electronic) 0028-3878 (Linking).

Links | BibTeX

Schwab, N.; Schneider-Hohendorf, T.; Pignolet, B.; Spadaro, M.; Gorlich, D.; Meinl, I.; Windhagen, S.; Tackenberg, B.; Breuer, J.; Canto, E.; Kumpfel, T.; Hohlfeld, R.; Siffrin, V.; Luessi, F.; Posevitz-Fejfar, A.; Montalban, X.; Meuth, S. G.; Zipp, F.; Gold, R.; Du Pasquier, R. A.; Kleinschnitz, C.; Jacobi, A.; Comabella, M.; Bertolotto, A.; Brassat, D.; Wiendl, H.

PML risk stratification using anti-JCV antibody index and L-selectin Journal Article

In: Mult Scler, vol. 22, no. 8, pp. 1048-60, 2016, ISSN: 1477-0970 (Electronic) 1352-4585 (Linking).

Links | BibTeX

Yshii, L. M.; Gebauer, C. M.; Pignolet, B.; Maure, E.; Queriault, C.; Pierau, M.; Saito, H.; Suzuki, N.; Brunner-Weinzierl, M.; Bauer, J.; Liblau, R.

CTLA4 blockade elicits paraneoplastic neurological disease in a mouse model Journal Article

In: Brain, 2016, ISSN: 1460-2156 (Electronic) 0006-8950 (Linking).

Links | BibTeX

Bernard-Valnet, R.; Yshii, L.; Queriault, C.; Nguyen, X. H.; Arthaud, S.; Rodrigues, M.; Canivet, A.; Morel, A. L.; Matthys, A.; Bauer, J.; Pignolet, B.; Dauvilliers, Y.; Peyron, C.; Liblau, R. S.

CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice Journal Article

In: Proc Natl Acad Sci U S A, vol. 113, no. 39, pp. 10956-61, 2016, ISSN: 1091-6490 (Electronic) 0027-8424 (Linking).

Links | BibTeX

Aloulou, M.; Carr, E. J.; Gador, M.; Bignon, A.; Liblau, R. S.; Fazilleau, N.; Linterman, M. A.

Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells Journal Article

In: Nat Commun, vol. 7, pp. 10579, 2016, ISSN: 2041-1723 (Electronic) 2041-1723 (Linking).

Links | BibTeX

Yshii, L. M.; Gebauer, C. M.; Pignolet, B.; Maure, E.; Queriault, C.; Pierau, M.; Saito, H.; Suzuki, N.; Brunner-Weinzierl, M.; Bauer, J.; Liblau, R.

CTLA4 blockade elicits paraneoplastic neurological disease in a mouse model Journal Article

In: Brain, 2016, ISSN: 1460-2156 (Electronic) 0006-8950 (Linking).

Links | BibTeX

Stienne, C.; Michieletto, M. F.; Benamar, M.; Carrie, N.; Bernard, I.; Nguyen, X. H.; Lippi, Y.; Duguet, F.; Liblau, R. S.; Hedrick, S. M.; Saoudi, A.; Dejean, A. S.

Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of Eomes Journal Article

In: Immunity, vol. 45, no. 4, pp. 774-787, 2016, ISSN: 1097-4180 (Electronic) 1074-7613 (Linking).

Links | BibTeX

Mansuy, J. M.; Suberbielle, E.; Chapuy-Regaud, S.; Mengelle, C.; Bujan, L.; Marchou, B.; Delobel, P.; Gonzalez-Dunia, D.; Malnou, C. E.; Izopet, J.; Martin-Blondel, G.

Zika virus in semen and spermatozoa Journal Article

In: Lancet Infect Dis, vol. 16, no. 10, pp. 1106-1107, 2016, ISSN: 1474-4457 (Electronic) 1473-3099 (Linking).

Links | BibTeX

Mansuy, J. M.; Dutertre, M.; Mengelle, C.; Fourcade, C.; Marchou, B.; Delobel, P.; Izopet, J.; Martin-Blondel, G.

Zika virus: high infectious viral load in semen, a new sexually transmitted pathogen? Journal Article

In: Lancet Infect Dis, vol. 16, no. 4, pp. 405, 2016, ISSN: 1474-4457 (Electronic) 1473-3099 (Linking).

Links | BibTeX

Hartmann, F. J.; Bernard-Valnet, R.; Queriault, C.; Mrdjen, D.; Weber, L. M.; Galli, E.; Krieg, C.; Robinson, M. D.; Nguyen, X. H.; Dauvilliers, Y.; Liblau, R. S.; Becher, B.

High-dimensional single-cell analysis reveals the immune signature of narcolepsy Journal Article

In: J Exp Med, vol. 213, no. 12, pp. 2621-2633, 2016, ISSN: 1540-9538 (Electronic) 0022-1007 (Linking).

Links | BibTeX

Kieback, E.; Hilgenberg, E.; Stervbo, U.; Lampropoulou, V.; Shen, P.; Bunse, M.; Jaimes, Y.; Boudinot, P.; Radbruch, A.; Klemm, U.; Kuhl, A. A.; Liblau, R.; Hoevelmeyer, N.; Anderton, S. M.; Uckert, W.; Fillatreau, S.

Thymus-Derived Regulatory T Cells Are Positively Selected on Natural Self-Antigen through Cognate Interactions of High Functional Avidity Journal Article

In: Immunity, vol. 44, no. 5, pp. 1114-26, 2016, ISSN: 1097-4180 (Electronic) 1074-7613 (Linking).

Links | BibTeX

Hartmann, F. J.; Bernard-Valnet, R.; Queriault, C.; Mrdjen, D.; Weber, L. M.; Galli, E.; Krieg, C.; Robinson, M. D.; Nguyen, X. H.; Dauvilliers, Y.; Liblau, R. S.; Becher, B.

High-dimensional single-cell analysis reveals the immune signature of narcolepsy Journal Article

In: J Exp Med, vol. 213, no. 12, pp. 2621-2633, 2016, ISSN: 1540-9538 (Electronic) 0022-1007 (Linking).

Links | BibTeX

2015

Martin-Blondel, G.; Bauer, J.; Uro-Coste, E.; Biotti, D.; Averseng-Peaureaux, D.; Fabre, N.; Dumas, H.; Bonneville, F.; Lassmann, H.; Marchou, B.; Liblau, R. S.; Brassat, D.

Therapeutic use of CCR5 antagonists is supported by strong expression of CCR5 on CD8(+) T cells in progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory syndrome Journal Article

In: Acta Neuropathol, vol. 129, no. 3, pp. 463-5, 2015, ISSN: 1432-0533 (Electronic) 0001-6322 (Linking).

Links | BibTeX

Hafler, D. A.; Astier, A. L.

Editorial: T cell regulation by the environment Journal Article

In: Front Immunol, vol. 6, pp. 229, 2015, ISSN: 1664-3224 (Print) 1664-3224 (Linking).

Links | BibTeX

Martin-Blondel, G.; Bauer, J.; Uro-Coste, E.; Biotti, D.; Averseng-Peaureaux, D.; Fabre, N.; Dumas, H.; Bonneville, F.; Lassmann, H.; Marchou, B.; Liblau, R. S.; Brassat, D.

Therapeutic use of CCR5 antagonists is supported by strong expression of CCR5 on CD8(+) T cells in progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory syndrome Journal Article

In: Acta Neuropathol, vol. 129, no. 3, pp. 463-5, 2015, ISSN: 1432-0533 (Electronic) 0001-6322 (Linking).

Links | BibTeX

Pedros, C.; Gaud, G.; Bernard, I.; Kassem, S.; Chabod, M.; Lagrange, D.; Andreoletti, O.; Dejean, A. S.; Lesourne, R.; Fournie, G. J.; Saoudi, A.

An Epistatic Interaction between Themis1 and Vav1 Modulates Regulatory T Cell Function and Inflammatory Bowel Disease Development Journal Article

In: J Immunol, vol. 195, no. 4, pp. 1608-16, 2015, ISSN: 1550-6606 (Electronic) 0022-1767 (Linking).

Links | BibTeX

2014

Outteryck, O.; Ongagna, J. C.; Brochet, B.; Rumbach, L.; Lebrun-Frenay, C.; Debouverie, M.; Zephir, H.; Ouallet, J. C.; Berger, E.; Cohen, M.; Pittion, S.; Laplaud, D.; Wiertlewski, S.; Cabre, P.; Pelletier, J.; Rico, A.; Defer, G.; Derache, N.; Camu, W.; Thouvenot, E.; Moreau, T.; Fromont, A.; Tourbah, A.; Labauge, P.; Castelnovo, G.; Clavelou, P.; Casez, O.; Hautecoeur, P.; Papeix, C.; Lubetzki, C.; Fontaine, B.; Couturier, N.; Bohossian, N.; Clanet, M.; Vermersch, P.; de Seze, J.; Brassat, D.; Network, Bionat; Cfsep,

A prospective observational post-marketing study of natalizumab-treated multiple sclerosis patients: clinical, radiological and biological features and adverse events. The BIONAT cohort Journal Article

In: Eur J Neurol, vol. 21, no. 1, pp. 40-8, 2014, ISSN: 1468-1331 (Electronic) 1351-5101 (Linking).

Links | BibTeX

2011

International Multiple Sclerosis Genetics, Consortium; Wellcome Trust Case Control, Consortium; Sawcer, S.; Hellenthal, G.; Pirinen, M.; Spencer, C. C.; Patsopoulos, N. A.; Moutsianas, L.; Dilthey, A.; Su, Z.; Freeman, C.; Hunt, S. E.; Edkins, S.; Gray, E.; Booth, D. R.; Potter, S. C.; Goris, A.; Band, G.; Oturai, A. B.; Strange, A.; Saarela, J.; Bellenguez, C.; Fontaine, B.; Gillman, M.; Hemmer, B.; Gwilliam, R.; Zipp, F.; Jayakumar, A.; Martin, R.; Leslie, S.; Hawkins, S.; Giannoulatou, E.; D'Alfonso, S.; Blackburn, H.; Martinelli Boneschi, F.; Liddle, J.; Harbo, H. F.; Perez, M. L.; Spurkland, A.; Waller, M. J.; Mycko, M. P.; Ricketts, M.; Comabella, M.; Hammond, N.; Kockum, I.; McCann, O. T.; Ban, M.; Whittaker, P.; Kemppinen, A.; Weston, P.; Hawkins, C.; Widaa, S.; Zajicek, J.; Dronov, S.; Robertson, N.; Bumpstead, S. J.; Barcellos, L. F.; Ravindrarajah, R.; Abraham, R.; Alfredsson, L.; Ardlie, K.; Aubin, C.; Baker, A.; Baker, K.; Baranzini, S. E.; Bergamaschi, L.; Bergamaschi, R.; Bernstein, A.; Berthele, A.; Boggild, M.; Bradfield, J. P.; Brassat, D.; Broadley, S. A.; Buck, D.; Butzkueven, H.; Capra, R.; Carroll, W. M.; Cavalla, P.; Celius, E. G.; Cepok, S.; Chiavacci, R.; Clerget-Darpoux, F.; Clysters, K.; Comi, G.; Cossburn, M.; Cournu-Rebeix, I.; Cox, M. B.; Cozen, W.; Cree, B. A.; Cross, A. H.; Cusi, D.; Daly, M. J.; Davis, E.; de Bakker, P. I.; Debouverie, M.; D'Hooghe M, B.; Dixon, K.; Dobosi, R.; Dubois, B.; Ellinghaus, D.; others,

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis Journal Article

In: Nature, vol. 476, no. 7359, pp. 214-9, 2011, ISSN: 1476-4687 (Electronic) 0028-0836 (Linking).

Links | BibTeX

Dejean, A. S.; Hedrick, S. M.; Kerdiles, Y. M.

Highly specialized role of Forkhead box O transcription factors in the immune system Journal Article

In: Antioxid Redox Signal, vol. 14, no. 4, pp. 663-74, 2011, ISSN: 1557-7716 (Electronic) 1523-0864 (Linking).

Links | BibTeX

Couturier, N.; Bucciarelli, F.; Nurtdinov, R. N.; Debouverie, M.; Lebrun-Frenay, C.; Defer, G.; Moreau, T.; Confavreux, C.; Vukusic, S.; Cournu-Rebeix, I.; Goertsches, R. H.; Zettl, U. K.; Comabella, M.; Montalban, X.; Rieckmann, P.; Weber, F.; Muller-Myhsok, B.; Edan, G.; Fontaine, B.; Mars, L. T.; Saoudi, A.; Oksenberg, J. R.; Clanet, M.; Liblau, R. S.; Brassat, D.

Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility Journal Article

In: Brain, vol. 134, no. Pt 3, pp. 693-703, 2011, ISSN: 1460-2156 (Electronic) 0006-8950 (Linking).

Links | BibTeX

Colacios, C.; Casemayou, A.; Dejean, A. S.; Gaits-Iacovoni, F.; Pedros, C.; Bernard, I.; Lagrange, D.; Deckert, M.; Lamouroux, L.; Jagodic, M.; Olsson, T.; Liblau, R. S.; Fournie, G. J.; Saoudi, A.

The p.Arg63Trp polymorphism controls Vav1 functions and Foxp3 regulatory T cell development Journal Article

In: J Exp Med, vol. 208, no. 11, pp. 2183-91, 2011, ISSN: 1540-9538 (Electronic) 0022-1007 (Linking).

Links | BibTeX

2009

Dejean, A. S.; Beisner, D. R.; Ch'en, I. L.; Kerdiles, Y. M.; Babour, A.; Arden, K. C.; Castrillon, D. H.; DePinho, R. A.; Hedrick, S. M.

Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells Journal Article

In: Nat Immunol, vol. 10, no. 5, pp. 504-13, 2009, ISSN: 1529-2916 (Electronic) 1529-2908 (Linking).

Links | BibTeX

Societal impact

Our team aims at understanding the cellular and molecular determinants leading to inflammation and autoimmunity in the central nervous system. To this end, we have generated unique genetically modified mouse models on which innovative research can be conducted ranging from mechanistic studies to pre-clinical therapeutic testing. We have also developed unique biological resources from patients with MS or narcolepsy that allow us to translate directly to the clinic the relevance of our key findings (identification or validation of pathways contributing to disease susceptibility, identification of new biomarkers). Finally, we are involved in investigator-initiated therapeutic trials that open new possibilities for patients with CNS inflammatory or infectious diseases.

Our team is composed of a mix of senior and more junior investigators from seven countries and diverse backgrounds (physician, scientist, veterinary, pharmacist…). This favors a vivid and dynamic scientific environment and provides unique opportunities to develop both basic and translational research and even investigator-sponsored clinical trials. We benefit from a solid international visibility in the field of neuroimmunology. National and international collaborations of the highest scientific level have been built over the years. These networks give access to both scientific inputs and technological expertise for our projects. Some of our current lines of research have raised interest from Biotech or Pharma such as GSK, Biogen and Genzyme providing possible alternative sources of funding, while keeping our research independent.
Our team has been successful in obtaining a number of grants for the proposed projects from local, national or international origins.

Alumni

Post-docs :

  • Mars Lennart T
  • Piaggio Eliane
  • Zapula Jacques
  • Scheikl Tanja
  • Lazarczyk Macjek
  • Céline Colacios
  • Lamouroux Lucile
  • Ramadan Raouf
  • Xuan-Hung Nguyen
  • Manish Malviya
  • Lidia Yshii
  • Guillaume Gaud
  • Myriam Hayder
  • Familiades Julien
  • Coralie Fonte
  • Sally Al-Hajj
  • Elena Morandi

 

PhD

  • Céline Meyer
  • Pierre-Paul Axisa
  • Guillaume Martin-Blondel
  • Michael Michieletto
  • Mehdi Benamar
  • Raphaël Bernard-Valnet
  • Lucca Liliana
  • Stienne Caroline
  • Gebauer Christina
  • Kassem Sahar
  • Pedros Christophe
  • Saxena Amit
  • Couturier Nicolas
  • Bergereau Emilie
  • Bohossian Nora
  • Ordonez Laurence
  • Casemaiyou Audrey
  • Duguet Fanny
  • Chabod Mariane
  • Cabarocas Julie
  • Cassan Cécile
  • Emeline Joulia
  • Arantxa Agesta
  • Leila Khajavi
  • Remi Marrocco
  • Arnaud Delbello
Collaborations
Becher Burkhard , Institute of Experimental Immunology, University of Zurich, Switzerland
Casanova Jean-Laurent , the Rockfeller University , NY, USA
Dauvilliers Yves, Department of Sleep Disorders, Montpellier, France
Engelhardt Britta, Theodor Kocher Institute, University of Bern, Switzerland
Hedrick Stephen M , UCSD, La jolla, CA, USA)
Lassmann Hans & Jan Bauer, Brain Research Institute, Vienne, Austria
Malissen Bernard, CIML, Marseille, France
Olsson Tomas, Karolinska Hospital, Stockholm, Sweden
Peyron Christelle, INSERM U1028, CNRS UMR 5292, Center for Research in Neuroscience, Lyon, France
Sarry Jean-Emmanuel , centre de recherche en cancérologie de Toulouse, FranceManuel Comabella VHIR, Barcelone, Spain
Schiltz Odile & Anne Gonzalez-de-Peredo, IPBS, Toulouse, France
Fernandes Adelaide, Lisbon, Portugal
Simon Michel, UDEAR, Toulouse, France
Tafti Mehdi, Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Thouvenot Eric, Institute of functional genomic, Montpellier, France
Walzer Thierry, Centre International de Recherche en Infectiologie, Lyon, France
Wiendl Heinz, Department of Neurology, University of Münster, Germany
Zytnicki Matthias, Unité de Mathématiques et Informatique Appliquées de Toulouse, France

Collaborations within the Center:

Daniel Dunia
Jacques Izopet
Jean-Charles Guery
Manuel Diaz-Munoz
Michel Simon
Nabila Jabrane
Nicolas Blanchard
Nicolas Fazilleau
Rémi Poupot
Renaut Lesourne
Sylvie Gerder
Loic Dupré
Joost van Meerwijk

Partenaires Equipe 5

ARSEP

ARSEP

Agence nationale de la recherche

Agence nationale de la recherche

Région Occitanie

Région Occitanie

AFM

AFM

GSK

GSK

Fondation Bettencourt Schueller

Fondation Bettencourt Schueller

Fondation maladies rares

Fondation maladies rares

CNRS

CNRS

ATIP AVENIR

ATIP AVENIR

Fondation ARC

Fondation ARC