Viral infection : persistence, host response and pathophysiology

Coordinators : J. Izopet, B. Lagane

Scientific Objectives


The main objective of our team is to improve the understanding of the pathophysiology of HIV-1 and Hepatitis E virus (HEV) infections, two important public health concerns worldwide. We focus on how viral and host determinants, and their interplay, shape the outcome of both infections. Important issues we are interested in include viral replication, transmission, dissemination and persistence in cells and tissues and pathogenesis. We also investigate the setting up of immune responses in the context of these infections, and conversely how dysregulation of their homeostasis contributes to pathogenesis. Finally, our activities extend to the study of the mechanisms of action of antiviral compounds and viral escape from treatments. Our proximity to the University Hospital, combined with our skills in basic and clinical research, enable us to carry out translational research and to adapt our activities to deal with health emergencies (e.g. SARS-CoV2 pandemic). We are committed to maintaining cutting-edge research implying investments in technological development. We are involved in student/post-doc teaching/training, hence contributing to the formation of future scientists.

Our projects


AXIS 1: HIV

Our areas of interest are virus transmission, cell tropism, viral dissemination and persistence in tissues, and the mechanisms of pathogenesis (CD4 T cell depletion and immune system dysregulation). Basic research on these themes is carried out by two closely complementary and interconnected groups: (i) HIV-1 cellular and tissue tropism (head: B. Lagane) and (ii) HIV-1 reservoirs and immune reconstitution in the gut mucosa of people living with HIV-1 (PLWH) on antiretroviral therapy (ART) (head: P. Delobel). We are also involved in translational research through development of two HIV immunotherapy clinical trials promoted and funded by ANRS-MIE and led by P. Delobel.


HIV-1 cellular and tissue tropisms

PI: B. Lagane; Participants: H. Chamma, D. Martres, T. Montagné, B. Puissant, S. Raymond, C Vellas

Our team has long been involved in characterizing the tropism of viral quasispecies in PLWH (Bioinformatics, 2020).  More recently, we have also investigated the determinants of HIV-1 transmission, through characterization of the genotypic/phenotypic properties of CXCR4-using HIV-1 envelope glycoproteins (Env) in recently infected individuals. Our studies have also aimed at better understanding the molecular details of Env/receptor interactions and their role in HIV-1 cellular tropism and pathogenesis. We have described how HIV-1 Envs influence CCR5 conformation (PLoS Pathog., 2018; Viruses, 2021) and functions (eLife, 2022), the mechanisms of the increased pathogenicity of CXCR4-using viruses (PLoS Pathog., 2021) and of macrophage infection (PLoS Pathog., 2022; J. Cell. Biol., 2023) and the mode of action of HIV-1 inhibitors (Molecules, 2023; Sci.Adv., 2023). Building on these findings, our studies are now divided into three research axes fully funded by ANRS-MIE and Sidaction:

(i) CCR5 signaling – role of the CCR5’s PDZ-domain binding motif (PBM) during HIV-1 infection. This work deals with CCR5 signaling and its role in health and disease. We aim to explore the role of novel PDZ-domain containing proteins we have recently identified as CCR5 interactors, in particular in HIV-1 entry, replication and dissemination (Participants: H. Chamma; Coll. C. Caillet-Saguy, Institut Pasteur).

(ii) Mapping of HIV-1 target CD4+ T cell subsets in secondary lymphoid organs (SLO). CD4+ T lymphocytes in secondary lymphoid organs (SLO) are sites of HIV-1 replication and reservoirs from the earliest stages of infection and undergo HIV-1-induced death, leading to AIDS. Using tonsils as a SLO model, we study both on isolated cells and in the tissue context the phenotype of CD4 T lymphocytes targeted by viruses isolated from recently infected individuals, and the consequences in viral replication, CD4 T cell depletion, the nature/size of reservoirs and latency-reversing strategies. (Participants: B. Puissant-Lubrano, S. Raymond, D. Martres and T. Montagné).

(iii) Mechanisms of HIV-1 infection of intestinal macrophages: role in viral persistence and rebound. We have identified compartmentalized HIV-1 reservoirs in myeloid cells in the intestinal mucosa of PLWH on ART, raising the questions of their origin, nature and role upon treatment interruption. We seek to characterize the cellular tropism of HIV-1 Envs from intestinal macrophages or CD4 T cells, the phenotype of intestinal macrophages through multiplexed confocal microscopy, the mechanisms of their infection and the biological properties of macrophage-derived viruses, in particular after reactivation of latently infected cells (Participants: C. Vellas, hiring of a post-doc in progress).

HIV-1 persistence in the gut and failure to reconstitute mucosal immunity under antiretroviral therapy

PI: Prof. P. Delobel; Participants: N. Collercandy, C. Vellas, M. Quaranta, M. Requena.

For several years, our group has been interested in better understanding the persistence of HIV-1 and the reconstitution of immunity in the intestinal mucosa under antiretroviral (ARV) treatment. Our work has focused on in vivo pathophysiological studies in people living with HIV-1 (PLWH) and the development of ex vivo models.
Reconstitution of CD4+ T lymphocytes in the intestinal mucosa of PLWH remains incomplete despite effective ARV treatment, and this is dissociated from the blood compartment and lymphoid organs. This lack of intestinal immune reconstitution is responsible for the persistence of impaired epithelial integrity, microbial translocation, and deleterious chronic mucosal and systemic inflammation.
Our work is mainly based on cohorts of PLWH on ARVs, and HIV-negative controls, recruited at the University Hospital of Toulouse, who underwent intestinal endoscopic biopsies at different levels of the intestinal tract (duodenum, ileum and colon) in the ANRS EP44 and EP61 GALT studies (PI: Prof. P. Delobel). A new study (GALT-2) is in preparation in which new colon biopsies will be collected.
We have also developed an ex vivo culture model of primary human enterocytes differentiated on transwells, which allow us to reproduce a polarized intestinal epithelium, as well as a histoculture model to study HIV infection in the microenvironment of intestinal tissue.
Key findings:

A disruption of chemotactic axes is involved in the failure to reconstitute the intestinal immune barrier in PLHIV on ARVs: We have shown that a defect in CD4+ T cell recruitment is involved in the incomplete immune reconstitution of the duodenal mucosa of PLWH on ARVs, due to an alteration of the CCL25-CCR9 axis (Mavigner et al. J Clin Invest 2012). We have also described an alteration in the CCL20-CCR6 axis, associated with a defect in the recruitment of CCR6+ T cells, particularly Th17, contributing to the Th17/Treg imbalance (Loiseau et al. Mucosal Immunol 2016). In contrast to Th17, we have shown that intestinal Th22s are normally reconstituted under ARV, with recruitment via the CCL28-CCR10 axis remaining functional, as an alternative to the deficient CCL20-CCR6 axis (Nayrac et al. Mucosal Immunol, 2021). We have also shown that pro-inflammatory CXCR3+ Th1 and CD8+ T memory effector lymphocytes are increased in the intestinal mucosa of PLWH on ARVs, and that these lymphocytes contribute to the defect in the production of CCL20, ligand of CCR6, and to the production of CXCL9/10/11, ligands of CXCR3, through an effect of IFN- and IL-18 on enterocytes, inducing a vicious cycle of pro-inflammatory cell recruitment (Loiseau et al. J Infect Dis 2019).
Molecular characterization of the HIV-1 reservoir in the intestinal compartment of PLWH on ARVs: In the ANRS EP61 GALT study, we demonstrated that the HIV-1 reservoir was enriched in intact proviral DNA in the colon compared to the blood. This intact proviral reservoir is associated with colonic CD4+ PD-1+TIGIT- T lymphocytes and low genetic diversity of viral quasispecies, suggesting clonal amplification of proviruses (Vellas et al. eBioMedicine 2024).
We have also characterized the HIV reservoir in intestinal monocytes/macrophages, showing a low frequency of infection of these myeloid cells compared to CD4+ T lymphocytes. Nevertheless, intact proviruses and non-integrated HIV-1 DNA can be detected in intestinal monocytes/macrophages. Compartmentalization of viral quasispecies between monocytes/macrophages and CD4+ T cells was also observed. The tropism of viral envelopes isolated from macrophages remained T-tropic, suggesting a mechanism of macrophage infection involving CD4+ T cells (Vellas et al. J Infect Dis 2024).

Ongoing work and projects:

Intestinal and blood translocated microbiota in PLWH on ARVs: A characterization of the intestinal microbiota, studied in stages at the duodenal, ileal and colonic levels, as well as blood translocated microbiota, has been performed in participants of the ANRS EP61 GALT study. Metabolomic studies in blood and intestinal tissue are also underway (coll. M. Serino, IRSD). We are studying the interactions between the microbiota and intestinal mucosal immunity in PLWH.
T V1 lymphocytes in the blood and intestine of PLWH on ARV: In a substudy of the ANRS EP61 GALT study, we characterized the phenotype, transcriptome, functional profile and TCR repertoire of V1 T lymphocytes in the blood and duodenum of PLWH and HIV-negative controls. We demonstrated a clonal expansion of V1 cells with TEMRA CX3CR1+ phenotype and cytotoxic profile in PLWH. Triggers for this expansion include CMV and changes in the gut and blood microbiota translocated in PLWH. The frequency of cytotoxic V1 CX3CR1+ T cells in the blood and duodenum appears to be negatively correlated with residual cell-associated HIV-1 RNA in these two compartments, suggesting a possible role for cytotoxic V1 T cells in controlling residual viral replication (Collercandy et al. submitted).
Phenotype, functions and trafficking of CX3CR1+ effector lymphocytes between blood and gut compartments in PLWH on ARVs: Following on from the work on T cells V1, we also set out to analyze CD8+ and NK T cells, which also express CX3CR1. These CX3CR1+ lymphocytes share a cytotoxic effector phenotype that is associated with the antitumor response in oncology, and may therefore also have an antiviral role in the elimination of HIV-infected cells. This ongoing work includes phenotypic and functional analysis of blood and intestinal CX3CR1+ lymphocytes from participants in the ANRS EP61 GALT study, as well as exploration of the CX3CL1-CX3CR1 chemotactic axis, including factors in the intestinal microenvironment (cytokines, microbiota) associated with CX3CL1 expression by enterocytes, and its cleavage into soluble form (Collercandy et al. in prep).
Intestinal resident memory T lymphocytes (TRM) during HIV-1 infection: mechanisms involved in their depletion and role in viral persistence under ARVs: The homeostasis of intestinal TRM seems to be particularly disturbed during HIV-1 infection, with our preliminary results showing a more pronounced depletion of TRM compared to non-TRM, and incomplete reconstitution under ARVs involving both CD4+ and CD8+ TRM, particularly in the colon. CD4+ TRM may be particularly susceptible to HIV-1 infection during the replicative phases of infection and may constitute a viral reservoir, including intact proviruses, in long-lived cells. Chronic inflammation of the intestinal mucosa in PLWH on ARVs could also reduce the effector functions of CD8+ TRM and their tissue retention, and favor the recirculation of ex-TRM cells. We plan to characterize intestinal TRM in PLWH, including the mechanisms involved in their reduction, their possible recirculation, and their role in HIV-1 persistence on ARVs.

AXIS 2: HEV

Pathogenesis of HEV infection

In collaboration with N. Blanchard, we will be implicated in the projet MOTIF :  iMpact of chrOnic infections on cogniTIve and motor Functions during aging (Participant: F. Abravanel).

HEV life cycle in hepatocytes and enterocytes

Role of autophagy regulators and endoplasmic reticulum quality proteins in HEV release from hepatocytes

PI: S Chapuy-Regaud, Participants: S Lhomme; J Izopet, a post-doc to be hired

The hepatitis e virus uses cell membranes to support replication and assembly, and to leaves the cell in the form of lipid-associated, quasi-enveloped particles. Our recent work shows the role of autophagy-associated proteins in the viral cycle. The expression of these proteins may be triggered by endoplasmic reticulum (ER) stress involving ERAD (endoplasmic reticulum-associated degradation). We aim to identify the regulators of autophagy and ER quality involved in the viral cycle and leading to the preferential release of viral particles at the apical pole of polarized epithelial cells.

 

Study of the molecular motifs conferring a replicative advantage to the virus-host recombinant variants of the hepatitis E virus.

PI: S Lhomme; Participants: J Izopet, S Chapuy-Regaud, N Jeanne, O Paronetto, a post-doc to be hired

Hepatitis E virus (HEV) is a leading cause of viral hepatitis. It can cause chronic hepatitis E, defined by the persistence of the virus for more than 3 months, in immunocompromised patients. Virus-host recombinant viruses (VHRVs) that have incorporated human gene fragments into the proline-rich region (PPR) of their genome have been described in chronically infected patients (Lhomme, JVI, 2014; Lhomme, Front Microbiol, 2020). These human gene fragments had various origins: ribosomal protein S17, S19, tyrosine aminotransferase, inter-alpha trypsin inhibitor and promoted HEV replication in vitro. Our most recent work showed that 5 recombinant variants had a replicative advantage: RNF19A, ZNF787, KIF1B, RPS17 and EEF1A1, while 2 had not : RNA18 and RPL6 (Paronetto et al., JVI, 2024). The mechanisms leading to this replicative advantage over viruses lacking the human gene fragment are currently unknown. With different approaches, we aim to identify these mechanisms.

 

 

Other details


Publications

2025

Kamar, N.; Marion, O.; Abravanel, F.; Esposito, L.; Bello, A. Del; Izopet, J.

Porcine-derived pancreatic enzyme replacement therapy: a cause of hepatitis E virus transmission? Journal Article

In: Gut, vol. 74, no. 2, pp. 331-332, 2025, ISSN: 1468-3288 (Electronic) 0017-5749 (Linking).

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2024

Paronetto, O.; Allioux, C.; Dimeglio, C.; Lobjois, L.; Jeanne, N.; Ranger, N.; Boineau, J.; Pucelle, M.; Demmou, S.; Abravanel, F.; Chapuy-Regaud, S.; Izopet, J.; Lhomme, S.

Characterization of virus‒host recombinant variants of the hepatitis E virus Journal Article

In: J Virol, vol. 98, no. 6, pp. e0029524, 2024, ISSN: 1098-5514 (Electronic) 0022-538X (Linking).

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Vellas, C.; Martres, D.; Requena, M.; Nayrac, M.; Collercandy, N.; Latour, J.; Barange, K.; Alric, L.; Martin-Blondel, G.; Izopet, J.; Lagane, B.; Delobel, P.

Compartmentalized HIV-1 reservoir in intestinal monocytes/macrophages on antiretroviral therapy Journal Article

In: J Infect Dis, 2024, ISSN: 1537-6613 (Electronic) 0022-1899 (Linking).

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Vellas, C.; Nayrac, M.; Collercandy, N.; Requena, M.; Jeanne, N.; Latour, J.; Dimeglio, C.; Cazabat, M.; Barange, K.; Alric, L.; Carrere, N.; Martin-Blondel, G.; Izopet, J.; Delobel, P.

Intact proviruses are enriched in the colon and associated with PD-1(+)TIGIT(-) mucosal CD4(+) T cells of people with HIV-1 on antiretroviral therapy Journal Article

In: EBioMedicine, vol. 100, pp. 104954, 2024, ISSN: 2352-3964 (Electronic) 2352-3964 (Linking).

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2023

Peron, J. M.; Larrue, H.; Izopet, J.; Buti, M.

The pressing need for a global HEV vaccine Journal Article

In: J Hepatol, vol. 79, no. 3, pp. 876-880, 2023, ISSN: 1600-0641 (Electronic) 0168-8278 (Linking).

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Abravanel, F.; Lhomme, S.; Marion, O.; Peron, J. M.; Kamar, N.; Izopet, J.

Diagnostic and management strategies for chronic hepatitis E infection Journal Article

In: Expert Rev Anti Infect Ther, vol. 21, no. 2, pp. 143-148, 2023, ISSN: 1744-8336 (Electronic) 1478-7210 (Linking).

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2022

Han, Mingyu; Cantaloube-Ferrieu, Vincent; Xie, Maorong; Armani-Tourret, Marie; Woottum, Marie; Pagès, Jean-Christophe; Colin, Philippe; Lagane, Bernard; Benichou, Serge

HIV-1 cell-to-cell spread overcomes the virus entry block of non-macrophage-tropic strains in macrophages Journal Article

In: PLoS pathogens, vol. 18, no. 5, pp. e1010335, 2022, ISSN: 1553-7374.

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Lhomme, S.; Fayard, A.; Mirafzal, S.; Carcenac, R.; Boyer, P.; Latour, J.; Brebion, A.; Bay, J. O.; Henquell, C.; Izopet, J.

Persistence of hepatitis E virus in the cerebrospinal fluid despite apparently successful ribavirin therapy Journal Article

In: J Antimicrob Chemother, vol. 77, no. 8, pp. 2300-2303, 2022, ISSN: 1460-2091 (Electronic) 0305-7453 (Linking).

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2021

Armani-Tourret, M.; Zhou, Z.; Gasser, R.; Staropoli, I.; Cantaloube-Ferrieu, V.; Benureau, Y.; Garcia-Perez, J.; Perez-Olmeda, M.; Lorin, V.; Puissant-Lubrano, B.; Assoumou, L.; Delaugerre, C.; Lelievre, J. D.; Levy, Y.; Mouquet, H.; Martin-Blondel, G.; Alcami, J.; Arenzana-Seisdedos, F.; Izopet, J.; Colin, P.; Lagane, B.

Mechanisms of HIV-1 evasion to the antiviral activity of chemokine CXCL12 indicate potential links with pathogenesis Journal Article

In: PLoS Pathog, vol. 17, no. 4, pp. e1009526, 2021, ISSN: 1553-7374 (Electronic) 1553-7366 (Linking).

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El Costa, H.; Gouilly, J.; Abravanel, F.; Bahraoui, E.; Peron, J. M.; Kamar, N.; Jabrane-Ferrat, N.; Izopet, J.

Effector memory CD8 T cell response elicits Hepatitis E Virus genotype 3 pathogenesis in the elderly Journal Article

In: PLoS Pathog, vol. 17, no. 2, pp. e1009367, 2021, ISSN: 1553-7374 (Electronic) 1553-7366 (Linking).

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Kamar, Nassim; Abravanel, Florence; Marion, Olivier; Romieu-Mourez, Raphaelle; Couat, Chloé; Del Bello, Arnaud; Izopet, Jacques

Assessment of 4 Doses of SARS-CoV-2 Messenger RNA-Based Vaccine in Recipients of a Solid Organ Transplant Journal Article

In: JAMA network open, vol. 4, no. 11, pp. e2136030, 2021, ISSN: 2574-3805.

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Lhomme, S.; Abravanel, F.; Cintas, P.; Izopet, J.

Hepatitis E Virus Infection: Neurological Manifestations and Pathophysiology Journal Article

In: Pathogens, vol. 10, no. 12, 2021, ISSN: 2076-0817 (Print) 2076-0817 (Linking).

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Abravanel, F.; Nicot, F.; Lhomme, S.; Cazabat, M.; Drumel, T.; Velay, A.; Latour, J.; Belliere, J.; Cintas, P.; Kamar, N.; Izopet, J.

Hepatitis E Virus Quasispecies in Cerebrospinal Fluid with Neurological Manifestations Journal Article

In: Vaccines, vol. 9, no. 10, 2021, ISSN: 2076-393X (Print) 2076-393X (Linking).

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Barrague, H.; Fontaine, J.; Abravanel, F.; Maure, E.; Peron, J. M.; Alric, L.; Dubois, M.; Izopet, J.; Champagne, E.

Mobilization of gammadelta T Cells and IL-10 Production at the Acute Phase of Hepatitis E Virus Infection in Cytomegalovirus Carriers Journal Article

In: J Immunol, vol. 206, no. 5, pp. 1027-1038, 2021, ISSN: 1550-6606 (Electronic) 0022-1767 (Linking).

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Nayrac, M.; Requena, M.; Loiseau, C.; Cazabat, M.; Suc, B.; Carrere, N.; Barange, K.; Alric, L.; Martin-Blondel, G.; Izopet, J.; Delobel, P.

Th22 cells are efficiently recruited in the gut by CCL28 as an alternative to CCL20 but do not compensate for the loss of Th17 cells in treated HIV-1-infected individuals Journal Article

In: Mucosal Immunol, vol. 14, no. 1, pp. 219-228, 2021, ISSN: 1935-3456 (Electronic) 1933-0219 (Linking).

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2020

Chen, Qian; Gouilly, Jordi; Ferrat, Yann J.; Espino, Ana; Glaziou, Quentin; Cartron, Géraldine; El Costa, Hicham; Al-Daccak, Reem; Jabrane-Ferrat, Nabila

Metabolic reprogramming by Zika virus provokes inflammation in human placenta Journal Article

In: Nature Communications, vol. 11, no. 1, 2020, ISSN: 2041-1723.

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Nayrac, Manon; Requena, Mary; Loiseau, Claire; Cazabat, Michelle; Suc, Bertrand; Carrere, Nicolas; Barange, Karl; Alric, Laurent; Martin-Blondel, Guillaume; Izopet, Jacques; Delobel, Pierre

Th22 cells are efficiently recruited in the gut by CCL28 as an alternative to CCL20 but do not compensate for the loss of Th17 cells in treated HIV-1-infected individuals Journal Article

In: Mucosal Immunology, vol. 14, no. 1, pp. 219–228, 2020, ISSN: 1933-0219, 1935-3456.

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Raymond, Stéphanie; Piffaut, Marie; Bigot, Jonathan; Cazabat, Michelle; Montes, Brigitte; Bertrand, Kevin; Martin-Blondel, Guillaume; Izopet, Jacques; Delobel, Pierre

Sexual transmission of an extensively drug-resistant HIV-1 strain Journal Article

In: The Lancet HIV, vol. 7, no. 8, pp. e529–e530, 2020, ISSN: 23523018.

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Marion, Olivier; Lhomme, Sebastien; Nayrac, Manon; Dubois, Martine; Pucelle, Mélanie; Requena, Mary; Migueres, Marion; Abravanel, Florence; Peron, Jean Marie; Carrere, Nicolas; Suc, Bertrand; Delobel, Pierre; Kamar, Nassim; Izopet, Jacques

Hepatitis E virus replication in human intestinal cells Journal Article

In: Gut, vol. 69, no. 5, pp. 901–910, 2020, ISSN: 0017-5749, 1468-3288.

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2019

Raymond, Stéphanie; Jeanne, Nicolas; Nicot, Florence; Lefebvre, Caroline; Carcenac, Romain; Minier, Luce; Chiabrando, Julie; Cazabat, Michelle; Delobel, Pierre; Izopet, Jacques

Long-term evolution of transmitted CXCR4-using HIV-1 under effective antiretroviral therapy Journal Article

In: AIDS (London, England), vol. 33, no. 13, pp. 1977–1985, 2019, ISSN: 1473-5571.

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Dimeglio, Chloé; Raymond, Stéphanie; Jeanne, Nicolas; Reynes, Christelle; Carcenac, Romain; Lefebvre, Caroline; Cazabat, Michelle; Nicot, Florence; Delobel, Pierre; Izopet, Jacques

THETA: A new genotypic approach for predicting HIV-1 CRF02-AG coreceptor usage Journal Article

In: Bioinformatics (Oxford, England), 2019, ISSN: 1367-4811.

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Marion, O.; Lhomme, S.; Del Bello, A.; Abravanel, F.; Esposito, L.; Hebral, A. L.; Lavayssiere, L.; Cointault, O.; Ribes, D.; Izopet, J.; Kamar, N.

Monitoring hepatitis E virus fecal shedding to optimize ribavirin treatment duration in chronically infected transplant patients Journal Article

In: J Hepatol, vol. 70, no. 1, pp. 206-209, 2019, ISSN: 1600-0641 (Electronic) 0168-8278 (Linking).

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Assoumou, L.; Bocket, L.; Pallier, C.; Grude, M.; Ait-Namane, R.; Izopet, J.; Raymond, S.; Charpentier, C.; Visseaux, B.; Wirden, M.; Trabaud, M. A.; Le Guillou-Guillemette, H.; Allaoui, C.; Henquell, C.; Krivine, A.; Dos Santos, G.; Delamare, C.; Bouvier-Alias, M.; Montes, B.; Ferre, V.; De Monte, A.; Signori-Schmuck, A.; Maillard, A.; Morand-Joubert, L.; Tumiotto, C.; Fafi-Kremer, S.; Amiel, C.; Barin, F.; Marque-Juillet, S.; Courdavault, L.; Vallet, S.; Beby-Defaux, A.; de Rougemont, A.; Fenaux, H.; Avettand-Fenoel, V.; Allardet-Servent, A.; Plantier, J. C.; Peytavin, G.; Calvez, V.; Chaix, M. L.; Descamps, D.; Group, Anrs Ac- Resistance Study

Stable prevalence of transmitted drug resistance mutations and increased circulation of non-B subtypes in antiretroviral-naive chronically HIV-infected patients in 2015/2016 in France Journal Article

In: J Antimicrob Chemother, 2019, ISSN: 1460-2091 (Electronic) 0305-7453 (Linking).

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Dimeglio, C.; Kania, D.; Mantono, J. M.; Kagone, T.; Zida, S.; Tassembedo, S.; Dicko, A.; Tinto, B.; Yaro, S.; Hien, H.; Rouamba, J.; Bicaba, B.; Medah, I.; Meda, N.; Traore, O.; Tuaillon, E.; Abravanel, F.; Izopet, J.

Hepatitis E Virus Infections among Patients with Acute Febrile Jaundice in Burkina Faso Journal Article

In: Viruses, vol. 11, no. 6, 2019, ISSN: 1999-4915 (Electronic) 1999-4915 (Linking).

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Dimeglio, C.; Raymond, S.; Nicot, F.; Jeanne, N.; Carcenac, R.; Lefebvre, C.; Izopet, J.; French National Agency for Research on, Aids; Viral Hepatitis, A. C. Resistance Study Group

Impact of the mutational load on the virological response to a first-line rilpivirine-based regimen Journal Article

In: J Antimicrob Chemother, vol. 74, no. 3, pp. 718-721, 2019, ISSN: 1460-2091 (Electronic) 0305-7453 (Linking).

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Guerveno, C.; Raymond, S.; Metsu, D.; Gandia, P.; Izopet, J.; Martin-Blondel, G.; Delobel, P.

HIV-1 escape in the central nervous system on elvitegravir-based antiretroviral therapy Journal Article

In: AIDS, vol. 33, no. 3, pp. 593-594, 2019, ISSN: 1473-5571 (Electronic) 0269-9370 (Linking).

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Lhomme, S.; DebRoy, S.; Kamar, N.; Abravanel, F.; Metsu, D.; Marion, O.; Dimeglio, C.; Cotler, S. J.; Izopet, J.; Dahari, H.

Plasma Hepatitis E Virus Kinetics in Solid Organ Transplant Patients Receiving Ribavirin Journal Article

In: Viruses, vol. 11, no. 7, 2019, ISSN: 1999-4915 (Electronic) 1999-4915 (Linking).

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Lhomme, S.; Gallian, P.; Dimeglio, C.; Assal, A.; Abravanel, F.; Tiberghien, P.; Izopet, J.

Viral load and clinical manifestations of hepatitis E virus genotype 3 infections Journal Article

In: J Viral Hepat, vol. 26, no. 9, pp. 1139-1142, 2019, ISSN: 1365-2893 (Electronic) 1352-0504 (Linking).

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Loiseau, C.; Requena, M.; Nayrac, M.; Mavigner, M.; Cazabat, M.; Iscache, A. L.; Carrere, N.; Suc, B.; Alric, L.; Izopet, J.; Delobel, P.

Increased CXCR3+ T Cells Impairs Recruitment of T-Helper Type 17 Cells via Interferon gamma and Interleukin 18 in the Small Intestine Mucosa During Treated HIV-1 Infection Journal Article

In: J Infect Dis, vol. 220, no. 5, pp. 830-840, 2019, ISSN: 1537-6613 (Electronic) 0022-1899 (Linking).

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Marion, O.; Capelli, N.; Lhomme, S.; Dubois, M.; Pucelle, M.; Abravanel, F.; Kamar, N.; Izopet, J.

Hepatitis E virus genotype 3 and capsid protein in the blood and urine of immunocompromised patients Journal Article

In: J Infect, vol. 78, no. 3, pp. 232-240, 2019, ISSN: 1532-2742 (Electronic) 0163-4453 (Linking).

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Mzoughi, O.; Teixido, M.; Planes, R.; Serrero, M.; Hamimed, I.; Zurita, E.; Moreno, M.; Granados, G.; Lakhdar-Ghazal, F.; BenMohamed, L.; Giralt, E.; Bahraoui, E.

Trimeric Heptad Repeat Synthetic Peptides HR1 and HR2 Efficiently Inhibit HIV-1 Entry Journal Article

In: Biosci Rep, 2019, ISSN: 1573-4935 (Electronic) 0144-8463 (Linking).

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Sayed, I. M.; Verhoye, L.; Montpellier, C.; Abravanel, F.; Izopet, J.; Cocquerel, L.; Meuleman, P.

Hepatitis E Virus (HEV) Open Reading Frame 2 Antigen Kinetics in Human-Liver Chimeric Mice and Its Impact on HEV Diagnosis Journal Article

In: J Infect Dis, vol. 220, no. 5, pp. 811-819, 2019, ISSN: 1537-6613 (Electronic) 0022-1899 (Linking).

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Dukhovny, A.; Lamkiewicz, K.; Chen, Q.; Fricke, M.; Jabrane-Ferrat, N.; Marz, M.; Jung, J. U.; Sklan, E. H.

A CRISPR Activation Screen Identifies Genes That Protect against Zika Virus Infection Journal Article

In: J Virol, vol. 93, no. 16, 2019, ISSN: 1098-5514 (Electronic) 0022-538X (Linking).

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Hocine, H. R.; Brunel, S.; Chen, Q.; Giustiniani, J.; San Roman, M. J.; Ferrat, Y. J.; Palacios, I.; de la Rosa, O.; Lombardo, E.; Bensussan, A.; Charron, D.; Jabrane-Ferrat, N.; Al-Daccak, R.

Extracellular Vesicles Released by Allogeneic Human Cardiac Stem/Progenitor Cells as Part of Their Therapeutic Benefit Journal Article

In: Stem Cells Transl Med, vol. 8, no. 9, pp. 911-924, 2019, ISSN: 2157-6580 (Electronic) 2157-6564 (Linking).

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Jabrane-Ferrat, N.

Features of Human Decidual NK Cells in Healthy Pregnancy and During Viral Infection Journal Article

In: Front Immunol, vol. 10, pp. 1397, 2019, ISSN: 1664-3224 (Electronic) 1664-3224 (Linking).

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Mansuy, J. M.; El Costa, H.; Gouilly, J.; Mengelle, C.; Pasquier, C.; Martin-Blondel, G.; Izopet, J.; Jabrane-Ferrat, N.

Peripheral Plasma and Semen Cytokine Response to Zika Virus in Humans Journal Article

In: Emerg Infect Dis, vol. 25, no. 4, pp. 823-825, 2019, ISSN: 1080-6059 (Electronic) 1080-6040 (Linking).

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Souriant, S.; Balboa, L.; Dupont, M.; Pingris, K.; Kviatcovsky, D.; Cougoule, C.; Lastrucci, C.; Bah, A.; Gasser, R.; Poincloux, R.; Raynaud-Messina, B.; Al Saati, T.; Inwentarz, S.; Poggi, S.; Morana, E. J.; Gonzalez-Montaner, P.; Corti, M.; Lagane, B.; Vergne, I.; Allers, C.; Kaushal, D.; Kuroda, M. J.; Sasiain, M. D. C.; Neyrolles, O.; Maridonneau-Parini, I.; Lugo-Villarino, G.; Verollet, C.

Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages Journal Article

In: Cell Rep, vol. 26, no. 13, pp. 3586-3599 e7, 2019, ISSN: 2211-1247 (Electronic).

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Kamar, N.; Abravanel, F.; Behrendt, P.; Hofmann, J.; Pageaux, G. P.; Barbet, C.; Moal, V.; Couzi, L.; Horvatits, T.; Man, R. A. De; Cassuto, E.; Elsharkawy, A. M.; Riezebos-Brilman, A.; Scemla, A.; Hillaire, S.; Donnelly, M. C.; Radenne, S.; Sayegh, J.; Garrouste, C.; Dumortier, J.; Glowaki, F.; Matignon, M.; Coilly, A.; Figueres, L.; Mousson, C.; Minello, A.; Dharancy, S.; Rerolle, J. P.; Lebray, P.; Etienne, I.; Perrin, P.; Choi, M.; Marion, O.; Izopet, J.; Hepatitis, E. Virus Ribavirin Study Group

Ribavirin for Hepatitis E Virus Infection After Organ Transplantation: A Large European Retrospective Multicenter Study Journal Article

In: Clin Infect Dis, 2019, ISSN: 1537-6591 (Electronic) 1058-4838 (Linking).

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2018

Jin, J.; Momboisse, F.; Boncompain, G.; Koensgen, F.; Zhou, Z.; Cordeiro, N.; Arenzana-Seisdedos, F.; Perez, F.; Lagane, B.; Kellenberger, E.; Brelot, A.

CCR5 adopts three homodimeric conformations that control cell surface delivery Journal Article

In: Sci Signal, vol. 11, no. 529, 2018, ISSN: 1937-9145 (Electronic) 1945-0877 (Linking).

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Colin, P.; Zhou, Z.; Staropoli, I.; Garcia-Perez, J.; Gasser, R.; Armani-Tourret, M.; Benureau, Y.; Gonzalez, N.; Jin, J.; Connell, B. J.; Raymond, S.; Delobel, P.; Izopet, J.; Lortat-Jacob, H.; Alcami, J.; Arenzana-Seisdedos, F.; Brelot, A.; Lagane, B.

CCR5 structural plasticity shapes HIV-1 phenotypic properties Journal Article

In: PLoS Pathog, vol. 14, no. 12, pp. e1007432, 2018, ISSN: 1553-7374 (Electronic) 1553-7366 (Linking).

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Lopes, P. P.; Todorov, G.; Pham, T. T.; Nesburn, A. B.; Bahraoui, E.; BenMohamed, L.

Laser Adjuvant-Assisted Peptide Vaccine Promotes Skin Mobilization of Dendritic Cells and Enhances Protective CD8(+) TEM and TRM Cell Responses against Herpesvirus Infection and Disease Journal Article

In: J Virol, vol. 92, no. 8, 2018, ISSN: 1098-5514 (Electronic) 0022-538X (Linking).

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Srivastava, R.; Hernandez-Ruiz, M.; Khan, A. A.; Fouladi, M. A.; Kim, G. J.; Ly, V. T.; Yamada, T.; Lam, C.; Sarain, S. A. B.; Boldbaatar, U.; Zlotnik, A.; Bahraoui, E.; BenMohamed, L.

CXCL17 Chemokine-Dependent Mobilization of CXCR8(+)CD8(+) Effector Memory and Tissue-Resident Memory T Cells in the Vaginal Mucosa Is Associated with Protection against Genital Herpes Journal Article

In: J Immunol, vol. 200, no. 8, pp. 2915-2926, 2018, ISSN: 1550-6606 (Electronic) 0022-1767 (Linking).

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Planes, R.; Serrero, M.; Leghmari, K.; BenMohamed, L.; Bahraoui, E.

HIV-1 Envelope Glycoproteins Induce the Production of TNF-alpha and IL-10 in Human Monocytes by Activating Calcium Pathway Journal Article

In: Sci Rep, vol. 8, no. 1, pp. 17215, 2018, ISSN: 2045-2322 (Electronic) 2045-2322 (Linking).

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Halfon, P.; Scholtes, C.; Izopet, J.; Larrat, S.; Trimoulet, P.; Zoulim, F.; Alric, L.; Metivier, S.; Leroy, V.; Ouzan, D.; de Ledinghen, V.; Mohamed, S.; Penaranda, G.; Khiri, H.; Thelu, M. A.; Plauzolles, A.; Chiche, L.; Bourliere, M.; Abravanel, F.

Baseline and post-treatment hepatitis C NS5A resistance in relapsed patients from a multicentric real-life cohort Journal Article

In: Antivir Ther, vol. 23, no. 4, pp. 307-314, 2018, ISSN: 2040-2058 (Electronic) 1359-6535 (Linking).

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Montpellier, C.; Wychowski, C.; Sayed, I. M.; Meunier, J. C.; Saliou, J. M.; Ankavay, M.; Bull, A.; Pillez, A.; Abravanel, F.; Helle, F.; Brochot, E.; Drobecq, H.; Farhat, R.; Aliouat-Denis, C. M.; Haddad, J. G.; Izopet, J.; Meuleman, P.; Goffard, A.; Dubuisson, J.; Cocquerel, L.

Hepatitis E Virus Lifecycle and Identification of 3 Forms of the ORF2 Capsid Protein Journal Article

In: Gastroenterology, vol. 154, no. 1, pp. 211-223 e8, 2018, ISSN: 1528-0012 (Electronic) 0016-5085 (Linking).

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Halfon, P.; Scholtes, C.; Izopet, J.; Larrat, S.; Trimoulet, P.; Zoulim, F.; Alric, L.; Metivier, S.; Leroy, V.; Ouzan, D.; de Ledinghen, V.; Mohamed, S.; Penaranda, G.; Khiri, H.; Thelu, M. A.; Plauzolles, A.; Chiche, L.; Bourliere, M.; Abravanel, F.

Retreatment with direct-acting antivirals of genotypes 1-3-4 hepatitis C patients who failed an anti-NS5A regimen in real world Journal Article

In: J Hepatol, vol. 68, no. 3, pp. 595-597, 2018, ISSN: 1600-0641 (Electronic) 0168-8278 (Linking).

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Kamar, N.; Del Bello, A.; Izopet, J.

Should Persistent Hepatitis E Virus Replication in Transplant Patients Be Tolerated? Journal Article

In: Transplantation, vol. 102, no. 2, pp. e84-e85, 2018, ISSN: 1534-6080 (Electronic) 0041-1337 (Linking).

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Raymond, S.; Nicot, F.; Pallier, C.; Bellecave, P.; Maillard, A.; Trabaud, M. A.; Morand-Joubert, L.; Rodallec, A.; Amiel, C.; Mourez, T.; Bocket, L.; Beby-Defaux, A.; Bouvier-Alias, M.; Lambert-Niclot, S.; Charpentier, C.; Malve, B.; Mirand, A.; Dina, J.; Le Guillou-Guillemette, H.; Marque-Juillet, S.; Signori-Schmuck, A.; Barin, F.; Si-Mohamed, A.; Avettand Fenoel, V.; Roussel, C.; Calvez, V.; Saune, K.; Marcelin, A. G.; Rodriguez, C.; Descamps, D.; Izopet, J.; French National Agency for Research on, Aids; Viral Hepatitis, A. C. Resistance Study Group

Impact of Human Immunodeficiency Virus Type 1 Minority Variants on the Virus Response to a Rilpivirine-Based First-line Regimen Journal Article

In: Clin Infect Dis, vol. 66, no. 10, pp. 1588-1594, 2018, ISSN: 1537-6591 (Electronic) 1058-4838 (Linking).

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Braun, P.; Delgado, R.; Drago, M.; Fanti, D.; Fleury, H.; Izopet, J.; Lombardi, A.; Mancon, A.; Marcos, M. A.; Saune, K.; S, O. Shea; Perez-Rivilla, A.; Ramble, J.; Trimoulet, P.; Vila, J.; Whittaker, D.; Artus, A.; Rhodes, D.

A European multicenter study on the analytical performance of the VERIS HBV assay Journal Article

In: J Clin Virol, vol. 99-100, pp. 50-56, 2018, ISSN: 1873-5967 (Electronic) 1386-6532 (Linking).

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Raymond, S.; Nicot, F.; Carcenac, R.; Lefebvre, C.; Jeanne, N.; Saune, K.; Delobel, P.; Izopet, J.

HIV-1 genotypic resistance testing using the Vela automated next-generation sequencing platform Journal Article

In: J Antimicrob Chemother, vol. 73, no. 5, pp. 1152-1157, 2018, ISSN: 1460-2091 (Electronic) 0305-7453 (Linking).

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Bisseux, M.; Colombet, J.; Mirand, A.; Roque-Afonso, A. M.; Abravanel, F.; Izopet, J.; Archimbaud, C.; Peigue-Lafeuille, H.; Debroas, D.; Bailly, J. L.; Henquell, C.

Monitoring human enteric viruses in wastewater and relevance to infections encountered in the clinical setting: a one-year experiment in central France, 2014 to 2015 Journal Article

In: Euro Surveill, vol. 23, no. 7, 2018, ISSN: 1560-7917 (Electronic) 1025-496X (Linking).

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Dalton, H. R.; Izopet, J.

Transmission and Epidemiology of Hepatitis E Virus Genotype 3 and 4 Infections Journal Article

In: Cold Spring Harb Perspect Med, vol. 8, no. 11, 2018, ISSN: 2157-1422 (Electronic) 2157-1422 (Linking).

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Mallet, V.; Sberro-Soussan, R.; Roque-Afonso, A. M.; Vallet-Pichard, A.; Deau, B.; Portal, A.; Chaix, M. L.; Hauser, L.; Beyloune, A.; Mercadier, A.; Izopet, J.; Legendre, C.; Pol, S.

Transmission of Hepatitis E Virus With Plasma Exchange in Kidney Transplant Recipients: A Retrospective Cohort Study Journal Article

In: Transplantation, vol. 102, no. 8, pp. 1351-1357, 2018, ISSN: 1534-6080 (Electronic) 0041-1337 (Linking).

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Kamar, N.; Pischke, S.

Acute and Persistent Hepatitis E Virus Genotype 3 and 4 Infection: Clinical Features, Pathogenesis, and Treatment Journal Article

In: Cold Spring Harb Perspect Med, 2018, ISSN: 2157-1422 (Electronic) 2157-1422 (Linking).

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Nicot, F.; Jeanne, N.; Raymond, S.; Delfour, O.; Carcenac, R.; Lefebvre, C.; Saune, K.; Delobel, P.; Izopet, J.

Performance comparison of deep sequencing platforms for detecting HIV-1 variants in the pol gene Journal Article

In: J Med Virol, vol. 90, no. 9, pp. 1486-1492, 2018, ISSN: 1096-9071 (Electronic) 0146-6615 (Linking).

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Lambert-Niclot, S.; Grude, M.; Meynard, J. L.; Marcelin, A. G.; Valantin, M. A.; Flandre, P.; Izopet, J.; Moinot, L.; Bouteloup, V.; Calvez, V.; Katlama, C.; Girard, P. M.; Morand-Joubert, L.

Ultrasensitive Human Immunodeficiency Virus Type 1 Viral Load as a Marker of Treatment Choice for Simplification Strategies Journal Article

In: Clin Infect Dis, vol. 67, no. 12, pp. 1883-1889, 2018, ISSN: 1537-6591 (Electronic) 1058-4838 (Linking).

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Grellier, J.; Hirsch, H. H.; Mengelle, C.; Esposito, L.; Hebral, A. L.; Belliere, J.; Weissbach, F.; Izopet, J.; Del Bello, A.; Kamar, N.

Impact of donor BK polyomavirus replication on recipient infections in living donor transplantation Journal Article

In: Transpl Infect Dis, vol. 20, no. 4, pp. e12917, 2018, ISSN: 1399-3062 (Electronic) 1398-2273 (Linking).

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Marion, O.; Abravanel, F.; Del Bello, A.; Esposito, L.; Lhomme, S.; Puissant-Lubrano, B.; Alric, L.; Faguer, S.; Izopet, J.; Kamar, N.

Hepatitis E virus-associated cryoglobulinemia in solid-organ-transplant recipients Journal Article

In: Liver Int, vol. 38, no. 12, pp. 2178-2189, 2018, ISSN: 1478-3231 (Electronic) 1478-3223 (Linking).

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Nicot, F.; Jeanne, N.; Roulet, A.; Lefebvre, C.; Carcenac, R.; Manno, M.; Dubois, M.; Kamar, N.; Lhomme, S.; Abravanel, F.; Izopet, J.

Diversity of hepatitis E virus genotype 3 Journal Article

In: Rev Med Virol, vol. 28, no. 5, pp. e1987, 2018, ISSN: 1099-1654 (Electronic) 1052-9276 (Linking).

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Abravanel, F.; Lhomme, S.; Chapuy-Regaud, S.; Mansuy, J. M.; Boineau, J.; Saune, K.; Izopet, J.

A fully automated system using transcription-mediated amplification for the molecular diagnosis of hepatitis E virus in human blood and faeces Journal Article

In: J Clin Virol, vol. 105, pp. 109-111, 2018, ISSN: 1873-5967 (Electronic) 1386-6532 (Linking).

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Abravanel, F.; Pique, J.; Couturier, E.; Nicot, F.; Dimeglio, C.; Lhomme, S.; Chiabrando, J.; Saune, K.; Peron, J. M.; Kamar, N.; Evrard, S.; de Valk, H.; Cintas, P.; Izopet, J.; group, H. E. V. study

Acute hepatitis E in French patients and neurological manifestations Journal Article

In: J Infect, vol. 77, no. 3, pp. 220-226, 2018, ISSN: 1532-2742 (Electronic) 0163-4453 (Linking).

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Mansuy, J. M.; Lhomme, S.; Cazabat, M.; Pasquier, C.; Martin-Blondel, G.; Izopet, J.

Detection of Zika, dengue and chikungunya viruses using single-reaction multiplex real-time RT-PCR Journal Article

In: Diagn Microbiol Infect Dis, vol. 92, no. 4, pp. 284-287, 2018, ISSN: 1879-0070 (Electronic) 0732-8893 (Linking).

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Raymond, S.; Delaugerre, C.; Nicot, F.; Assoumou, L.; Lancar, R.; Beniguel, L.; Izopet, J.; group, Anrs Optimal study

Accurate quantification of CXCR4-using HIV-1 variants by Illumina deep-sequencing Journal Article

In: AIDS, vol. 32, no. 16, pp. 2429-2431, 2018, ISSN: 1473-5571 (Electronic) 0269-9370 (Linking).

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Jadoul, M.; Berenguer, M. C.; Doss, W.; Fabrizi, F.; Izopet, J.; Jha, V.; Kamar, N.; Kasiske, B. L.; Lai, C. L.; Morales, J. M.; Patel, P. R.; Pol, S.; Silva, M. O.; Balk, E. M.; Gordon, C. E.; Earley, A.; Di, M.; Martin, P.

Executive summary of the 2018 KDIGO Hepatitis C in CKD Guideline: welcoming advances in evaluation and management Journal Article

In: Kidney Int, vol. 94, no. 4, pp. 663-673, 2018, ISSN: 1523-1755 (Electronic) 0085-2538 (Linking).

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Abravanel, F.; Lacipiere, A.; Lhomme, S.; Dubois, M.; Minier, L.; Peron, J. M.; Alric, L.; Kamar, N.; Izopet, J.

Performance of a commercial assay for detecting and quantifying HEV RNA in faeces Journal Article

In: J Clin Virol, vol. 109, pp. 1-5, 2018, ISSN: 1873-5967 (Electronic) 1386-6532 (Linking).

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Capelli, N.; Marion, O.; Dubois, M.; Allart, S.; Bertrand-Michel, J.; Lhomme, S.; Abravanel, F.; Izopet, J.; Chapuy-Regaud, S.

Vectorial Release of Hepatitis E Virus in Polarized Human Hepatocytes Journal Article

In: J Virol, 2018, ISSN: 1098-5514 (Electronic) 0022-538X (Linking).

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Dimeglio, C.; Beau, F.; Broult, J.; Gouy, P.; Izopet, J.; Lastere, S.; Abravanel, F.

Hepatitis E prevalence in French Polynesian blood donors Journal Article

In: PLoS One, vol. 13, no. 12, pp. e0208934, 2018, ISSN: 1932-6203 (Electronic) 1932-6203 (Linking).

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Dimeglio, C.; Raymond, S.; Nicot, F.; Jeanne, N.; Carcenac, R.; Lefebvre, C.; Izopet, J.; French National Agency for Research on, Aids; Viral Hepatitis, A. C. Resistance Study Group

Impact of the mutational load on the virological response to a first-line rilpivirine-based regimen Journal Article

In: J Antimicrob Chemother, 2018, ISSN: 1460-2091 (Electronic) 0305-7453 (Linking).

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Gouilly, J.; Chen, Q.; Siewiera, J.; Cartron, G.; Levy, C.; Dubois, M.; Al-Daccak, R.; Izopet, J.; Jabrane-Ferrat, N.; El Costa, H.

Genotype specific pathogenicity of hepatitis E virus at the human maternal-fetal interface Journal Article

In: Nat Commun, vol. 9, no. 1, pp. 4748, 2018, ISSN: 2041-1723 (Electronic) 2041-1723 (Linking).

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2017

Lhomme, S.; Bardiaux, L.; Abravanel, F.; Gallian, P.; Kamar, N.; Izopet, J.

Hepatitis E Virus Infection in Solid Organ Transplant Recipients, France Journal Article

In: Emerg Infect Dis, vol. 23, no. 2, pp. 353-356, 2017, ISSN: 1080-6059 (Electronic) 1080-6040 (Linking).

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Srivastava, R.; Khan, A. A.; Chilukuri, S.; Syed, S. A.; Tran, T. T.; Furness, J.; Bahraoui, E.; BenMohamed, L.

CXCL10/CXCR3-Dependent Mobilization of Herpes Simplex Virus-Specific CD8(+) TEM and CD8(+) TRM Cells within Infected Tissues Allows Efficient Protection against Recurrent Herpesvirus Infection and Disease Journal Article

In: J Virol, vol. 91, no. 14, 2017, ISSN: 1098-5514 (Electronic) 0022-538X (Linking).

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Serrero, M.; Planes, R.; Bahraoui, E.

PKC-delta isoform plays a crucial role in Tat-TLR4 signalling pathway to activate NF-kappaB and CXCL8 production Journal Article

In: Sci Rep, vol. 7, no. 1, pp. 2384, 2017, ISSN: 2045-2322 (Electronic) 2045-2322 (Linking).

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Donnelly, M. C.; Imlach, S. N.; Abravanel, F.; Ramalingam, S.; Johannessen, I.; Petrik, J.; Fraser, A. R.; Campbell, J. D.; Bramley, P.; Dalton, H. R.; Hayes, P. C.; Kamar, N.; Simpson, K. J.

Sofosbuvir and Daclatasvir Anti-Viral Therapy Fails to Clear HEV Viremia and Restore Reactive T Cells in a HEV/HCV Co-Infected Liver Transplant Recipient Journal Article

In: Gastroenterology, vol. 152, no. 1, pp. 300-301, 2017, ISSN: 1528-0012 (Electronic) 0016-5085 (Linking).

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Abravanel, F.; Lhomme, S.; Fougere, M.; Saune, K.; Alvarez, M.; Peron, J. M.; Delobel, P.; Izopet, J.

HEV infection in French HIV-infected patients Journal Article

In: J Infect, vol. 74, no. 3, pp. 310-313, 2017, ISSN: 1532-2742 (Electronic) 0163-4453 (Linking).

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Raymond, S.; Nicot, F.; Jeanne, N.; Delfour, O.; Carcenac, R.; Lefebvre, C.; Cazabat, M.; Saune, K.; Delobel, P.; Izopet, J.

Performance comparison of next-generation sequencing platforms for determining HIV-1 coreceptor use Journal Article

In: Sci Rep, vol. 7, pp. 42215, 2017, ISSN: 2045-2322 (Electronic) 2045-2322 (Linking).

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Sayed, I. M.; Foquet, L.; Verhoye, L.; Abravanel, F.; Farhoudi, A.; Leroux-Roels, G.; Izopet, J.; Meuleman, P.

Transmission of hepatitis E virus infection to human-liver chimeric FRG mice using patient plasma Journal Article

In: Antiviral Res, vol. 141, pp. 150-154, 2017, ISSN: 1872-9096 (Electronic) 0166-3542 (Linking).

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Abravanel, F.; Goutagny, N.; Perret, C.; Lhomme, S.; Vischi, F.; Aversenq, A.; Chapel, A.; Dehainault, N.; Piga, N.; Dupret-Carruel, J.; Izopet, J.

Evaluation of two VIDAS ((R))prototypes for detecting anti-HEV IgG Journal Article

In: J Clin Virol, vol. 89, pp. 46-50, 2017, ISSN: 1873-5967 (Electronic) 1386-6532 (Linking).

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Mansuy, J. M.; Mengelle, C.; Pasquier, C.; Chapuy-Regaud, S.; Delobel, P.; Martin-Blondel, G.; Izopet, J.

Zika Virus Infection and Prolonged Viremia in Whole-Blood Specimens Journal Article

In: Emerg Infect Dis, vol. 23, no. 5, pp. 863-865, 2017, ISSN: 1080-6059 (Electronic) 1080-6040 (Linking).

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Pasquier, C.; Saune, K.; Raymond, S.; Boisneau, J.; Courtade, M.; Izopet, J.

Comparison of Cobas(R) HPV and Anyplex II HPV28 assays for detecting and genotyping human papillomavirus Journal Article

In: Diagn Microbiol Infect Dis, vol. 87, no. 1, pp. 25-27, 2017, ISSN: 1879-0070 (Electronic) 0732-8893 (Linking).

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Kamar, N.; Wang, W.; Dalton, H. R.; Pan, Q.

Direct-acting antiviral therapy for hepatitis E virus? Journal Article

In: Lancet Gastroenterol Hepatol, vol. 2, no. 3, pp. 154-155, 2017, ISSN: 2468-1253 (Electronic).

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Velay, A.; Kack-Kack, W.; Abravanel, F.; Lhomme, S.; Leyendecker, P.; Kremer, L.; Chamouard, P.; Izopet, J.; Fafi-Kremer, S.; Barth, H.

Parsonage-Turner syndrome due to autochthonous acute genotype 3f hepatitis E virus infection in a nonimmunocompromised 55-year-old patient Journal Article

In: J Neurovirol, vol. 23, no. 4, pp. 615-620, 2017, ISSN: 1538-2443 (Electronic) 1355-0284 (Linking).

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Chapuy-Regaud, S.; Dubois, M.; Plisson-Chastang, C.; Bonnefois, T.; Lhomme, S.; Bertrand-Michel, J.; You, B.; Simoneau, S.; Gleizes, P. E.; Flan, B.; Abravanel, F.; Izopet, J.

Characterization of the lipid envelope of exosome encapsulated HEV particles protected from the immune response Journal Article

In: Biochimie, vol. 141, pp. 70-79, 2017, ISSN: 1638-6183 (Electronic) 0300-9084 (Linking).

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Dorr, G.; Del Bello, A.; Abravanel, F.; Marion, O.; Cointault, O.; Ribes, D.; Lavayssiere, L.; Esposito, L.; Nogier, M. B.; Hebral, A. L.; Saune, K.; Izopet, J.; Kamar, N.

Malignancies in hepatitis C virus-positive and -negative kidney transplant recipients: A case-controlled study Journal Article

In: Transpl Infect Dis, vol. 19, no. 4, 2017, ISSN: 1399-3062 (Electronic) 1398-2273 (Linking).

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Yin, X.; Li, X.; Ambardekar, C.; Hu, Z.; Lhomme, S.; Feng, Z.

Hepatitis E virus persists in the presence of a type III interferon response Journal Article

In: PLoS Pathog, vol. 13, no. 5, pp. e1006417, 2017, ISSN: 1553-7374 (Electronic) 1553-7366 (Linking).

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Metsu, D.; Toutain, P. L.; Chatelut, E.; Delobel, P.; Gandia, P.

Antiretroviral unbound concentration during pregnancy: piece of interest in the puzzle? Journal Article

In: J Antimicrob Chemother, vol. 72, no. 9, pp. 2407-2409, 2017, ISSN: 1460-2091 (Electronic) 0305-7453 (Linking).

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Abravanel, F.; Lhomme, S.; El Costa, H.; Schvartz, B.; Peron, J. M.; Kamar, N.; Izopet, J.

Rabbit Hepatitis E Virus Infections in Humans, France Journal Article

In: Emerg Infect Dis, vol. 23, no. 7, pp. 1191-1193, 2017, ISSN: 1080-6059 (Electronic) 1080-6040 (Linking).

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Moulin, M.; Alguacil, J.; Gu, S.; Mehtougui, A.; Adams, E. J.; Peyrottes, S.; Champagne, E.

Vgamma9Vdelta2 T cell activation by strongly agonistic nucleotidic phosphoantigens Journal Article

In: Cell Mol Life Sci, vol. 74, no. 23, pp. 4353-4367, 2017, ISSN: 1420-9071 (Electronic) 1420-682X (Linking).

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Izopet, J.; Lhomme, S.; Chapuy-Regaud, S.; Mansuy, J. M.; Kamar, N.; Abravanel, F.

HEV and transfusion-recipient risk Journal Article

In: Transfus Clin Biol, vol. 24, no. 3, pp. 176-181, 2017, ISSN: 1953-8022 (Electronic) 1246-7820 (Linking).

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Dalton, H. R.; van Eijk, J. J. J.; Cintas, P.; Madden, R. G.; Jones, C.; Webb, G. W.; Norton, B.; Pique, J.; Lutgens, S.; Devooght-Johnson, N.; Woolson, K.; Baker, J.; Saunders, M.; Househam, L.; Griffiths, J.; Abravanel, F.; Izopet, J.; Kamar, N.; van Alfen, N.; van Engelen, B. G. M.; Hunter, J. G.; van der Eijk, A. A.; Bendall, R. P.; McLean, B. N.; Jacobs, B. C.

Hepatitis E virus infection and acute non-traumatic neurological injury: A prospective multicentre study Journal Article

In: J Hepatol, vol. 67, no. 5, pp. 925-932, 2017, ISSN: 1600-0641 (Electronic) 0168-8278 (Linking).

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Joguet, G.; Mansuy, J. M.; Matusali, G.; Hamdi, S.; Walschaerts, M.; Pavili, L.; Guyomard, S.; Prisant, N.; Lamarre, P.; Dejucq-Rainsford, N.; Pasquier, C.; Bujan, L.

Effect of acute Zika virus infection on sperm and virus clearance in body fluids: a prospective observational study Journal Article

In: Lancet Infect Dis, vol. 17, no. 11, pp. 1200-1208, 2017, ISSN: 1474-4457 (Electronic) 1473-3099 (Linking).

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Pasquier, C.; Walschaerts, M.; Raymond, S.; Moinard, N.; Saune, K.; Daudin, M.; Izopet, J.; Bujan, L.

Patterns of residual HIV-1 RNA shedding in the seminal plasma of patients on effective antiretroviral therapy Journal Article

In: Basic Clin Androl, vol. 27, pp. 17, 2017, ISSN: 2051-4190 (Print) 2051-4190 (Linking).

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Barrague, H.; Condat, B.; Petitdidier, N.; Champagne, E.; Renou, C.; Izopet, J.; Abravanel, F.

Chronic hepatitis E virus infection in a cirrhotic patient: A case report Journal Article

In: Medicine (Baltimore), vol. 96, no. 39, pp. e7915, 2017, ISSN: 1536-5964 (Electronic) 0025-7974 (Linking).

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Belliere, J.; Abravanel, F.; Nogier, M. B.; Martinez, S.; Cintas, P.; Lhomme, S.; Lavayssiere, L.; Cointault, O.; Faguer, S.; Izopet, J.; Kamar, N.

Transfusion-acquired hepatitis E infection misdiagnosed as severe critical illness polyneuromyopathy in a heart transplant patient Journal Article

In: Transpl Infect Dis, vol. 19, no. 6, 2017, ISSN: 1399-3062 (Electronic) 1398-2273 (Linking).

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Kamar, N.; Izopet, J.; Pavio, N.; Aggarwal, R.; Labrique, A.; Wedemeyer, H.; Dalton, H. R.

Hepatitis E virus infection Journal Article

In: Nat Rev Dis Primers, vol. 3, pp. 17086, 2017, ISSN: 2056-676X (Electronic) 2056-676X (Linking).

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de Truchis, P.; Assoumou, L.; Landman, R.; Mathez, D.; Le Du, D.; Bellet, J.; Amat, K.; Katlama, C.; Gras, G.; Bouchaud, O.; Duracinsky, M.; Abe, E.; Alvarez, J. C.; Izopet, J.; Saillard, J.; Melchior, J. C.; Leibowitch, J.; Costagliola, D.; Girard, P. M.; Perronne, C.; Group, Anrs D. Study

Four-days-a-week antiretroviral maintenance therapy in virologically controlled HIV-1-infected adults: the ANRS 162-4D trial Journal Article

In: J Antimicrob Chemother, 2017, ISSN: 1460-2091 (Electronic) 0305-7453 (Linking).

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Hocine, H. R.; Costa, H. E.; Dam, N.; Giustiniani, J.; Palacios, I.; Loiseau, P.; Bensussan, A.; Borlado, L. R.; Charron, D.; Suberbielle, C.; Jabrane-Ferrat, N.; Al-Daccak, R.

Minimizing the risk of allo-sensitization to optimize the benefit of allogeneic cardiac-derived stem/progenitor cells Journal Article

In: Sci Rep, vol. 7, pp. 41125, 2017, ISSN: 2045-2322 (Electronic) 2045-2322 (Linking).

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Dam, N.; Hocine, H. R.; Palacios, I.; DelaRosa, O.; Menta, R.; Charron, D.; Bensussan, A.; El Costa, H.; Jabrane-Ferrat, N.; Dalemans, W.; Lombardo, E.; Al-Daccak, R.

Human Cardiac-Derived Stem/Progenitor Cells Fine-Tune Monocyte-Derived Descendants Activities toward Cardiac Repair Journal Article

In: Front Immunol, vol. 8, pp. 1413, 2017, ISSN: 1664-3224 (Print) 1664-3224 (Linking).

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2016

Abravanel, F.; Barrague, H.; Dorr, G.; Saune, K.; Peron, J. M.; Alric, L.; Kamar, N.; Izopet, J.; Champagne, E.

Conventional and innate lymphocytes response at the acute phase of HEV infection in transplanted patients Journal Article

In: J Infect, vol. 72, no. 6, pp. 723-730, 2016, ISSN: 1532-2742 (Electronic) 0163-4453 (Linking).

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Gasser, R.; Hamoudi, M.; Pellicciotta, M.; Zhou, Z.; Visdeloup, C.; Colin, P.; Braibant, M.; Lagane, B.; Negroni, M.

Buffering deleterious polymorphisms in highly constrained parts of HIV-1 envelope by flexible regions Journal Article

In: Retrovirology, vol. 13, no. 1, pp. 50, 2016, ISSN: 1742-4690 (Electronic) 1742-4690 (Linking).

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Loiseau, C.; Requena, M.; Mavigner, M.; Cazabat, M.; Carrere, N.; Suc, B.; Barange, K.; Alric, L.; Marchou, B.; Massip, P.; Izopet, J.; Delobel, P.

CCR6(-) regulatory T cells blunt the restoration of gut Th17 cells along the CCR6-CCL20 axis in treated HIV-1-infected individuals Journal Article

In: Mucosal Immunol, vol. 9, no. 5, pp. 1137-50, 2016, ISSN: 1935-3456 (Electronic) 1933-0219 (Linking).

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Mansuy, J. M.; Dutertre, M.; Mengelle, C.; Fourcade, C.; Marchou, B.; Delobel, P.; Izopet, J.; Martin-Blondel, G.

Zika virus: high infectious viral load in semen, a new sexually transmitted pathogen? Journal Article

In: Lancet Infect Dis, vol. 16, no. 4, pp. 405, 2016, ISSN: 1474-4457 (Electronic) 1473-3099 (Linking).

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Benureau, Y.; Colin, P.; Staropoli, I.; Gonzalez, N.; Garcia-Perez, J.; Alcami, J.; Arenzana-Seisdedos, F.; Lagane, B.

Guidelines for cloning, expression, purification and functional characterization of primary HIV-1 envelope glycoproteins Journal Article

In: J Virol Methods, vol. 236, pp. 184-95, 2016, ISSN: 1879-0984 (Electronic) 0166-0934 (Linking).

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Planes, R.; Ben Haij, N.; Leghmari, K.; Serrero, M.; BenMohamed, L.; Bahraoui, E.

HIV-1 Tat Protein Activates both the MyD88 and TRIF Pathways To Induce Tumor Necrosis Factor Alpha and Interleukin-10 in Human Monocytes Journal Article

In: J Virol, vol. 90, no. 13, pp. 5886-5898, 2016, ISSN: 1098-5514 (Electronic) 0022-538X (Linking).

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El Costa, H.; Gouilly, J.; Mansuy, J. M.; Chen, Q.; Levy, C.; Cartron, G.; Veas, F.; Al-Daccak, R.; Izopet, J.; Jabrane-Ferrat, N.

ZIKA virus reveals broad tissue and cell tropism during the first trimester of pregnancy Journal Article

In: Sci Rep, vol. 6, pp. 35296, 2016, ISSN: 2045-2322 (Electronic) 2045-2322 (Linking).

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2015

Garcia-Perez, J.; Staropoli, I.; Azoulay, S.; Heinrich, J. T.; Cascajero, A.; Colin, P.; Lortat-Jacob, H.; Arenzana-Seisdedos, F.; Alcami, J.; Kellenberger, E.; Lagane, B.

A single-residue change in the HIV-1 V3 loop associated with maraviroc resistance impairs CCR5 binding affinity while increasing replicative capacity Journal Article

In: Retrovirology, vol. 12, pp. 50, 2015, ISSN: 1742-4690 (Electronic) 1742-4690 (Linking).

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Jeanne, N.; Saliou, A.; Carcenac, R.; Lefebvre, C.; Dubois, M.; Cazabat, M.; Nicot, F.; Loiseau, C.; Raymond, S.; Izopet, J.; Delobel, P.

Position-specific automated processing of V3 env ultra-deep pyrosequencing data for predicting HIV-1 tropism Journal Article

In: Sci Rep, vol. 5, pp. 16944, 2015, ISSN: 2045-2322 (Electronic) 2045-2322 (Linking).

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Lhomme, S.; Kamar, N.; Nicot, F.; Ducos, J.; Bismuth, M.; Garrigue, V.; Petitjean-Lecherbonnier, J.; Ollivier, I.; Alessandri-Gradt, E.; Goria, O.; Barth, H.; Perrin, P.; Saune, K.; Dubois, M.; Carcenac, R.; Lefebvre, C.; Jeanne, N.; Abravanel, F.; Izopet, J.

Mutation in the Hepatitis E Virus Polymerase and Outcome of Ribavirin Therapy Journal Article

In: Antimicrob Agents Chemother, vol. 60, no. 3, pp. 1608-14, 2015, ISSN: 1098-6596 (Electronic) 0066-4804 (Linking).

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Ben Haij, N.; Planes, R.; Leghmari, K.; Serrero, M.; Delobel, P.; Izopet, J.; BenMohamed, L.; Bahraoui, E.

HIV-1 Tat Protein Induces Production of Proinflammatory Cytokines by Human Dendritic Cells and Monocytes/Macrophages through Engagement of TLR4-MD2-CD14 Complex and Activation of NF-kappaB Pathway Journal Article

In: PLoS One, vol. 10, no. 6, pp. e0129425, 2015, ISSN: 1932-6203 (Electronic) 1932-6203 (Linking).

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Ainaoui, N.; Hantelys, F.; Renaud-Gabardos, E.; Bunel, M.; Lopez, F.; Pujol, F.; Planes, R.; Bahraoui, E.; Pichereaux, C.; Burlet-Schiltz, O.; Parini, A.; Garmy-Susini, B.; Prats, A. C.

Promoter-Dependent Translation Controlled by p54nrb and hnRNPM during Myoblast Differentiation Journal Article

In: PLoS One, vol. 10, no. 9, pp. e0136466, 2015, ISSN: 1932-6203 (Electronic) 1932-6203 (Linking).

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Siewiera, J.; Gouilly, J.; Hocine, H. R.; Cartron, G.; Levy, C.; Al-Daccak, R.; Jabrane-Ferrat, N.

Natural cytotoxicity receptor splice variants orchestrate the distinct functions of human natural killer cell subtypes Journal Article

In: Nat Commun, vol. 6, pp. 10183, 2015, ISSN: 2041-1723 (Electronic) 2041-1723 (Linking).

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2014

Kamar, N.; Izopet, J.; Tripon, S.; Bismuth, M.; Hillaire, S.; Dumortier, J.; Radenne, S.; Coilly, A.; Garrigue, V.; D'Alteroche, L.; Buchler, M.; Couzi, L.; Lebray, P.; Dharancy, S.; Minello, A.; Hourmant, M.; Roque-Afonso, A. M.; Abravanel, F.; Pol, S.; Rostaing, L.; Mallet, V.

Ribavirin for chronic hepatitis E virus infection in transplant recipients Journal Article

In: N Engl J Med, vol. 370, no. 12, pp. 1111-20, 2014, ISSN: 1533-4406 (Electronic) 0028-4793 (Linking).

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Planes, R.; BenMohamed, L.; Leghmari, K.; Delobel, P.; Izopet, J.; Bahraoui, E.

HIV-1 Tat protein induces PD-L1 (B7-H1) expression on dendritic cells through tumor necrosis factor alpha- and toll-like receptor 4-mediated mechanisms Journal Article

In: J Virol, vol. 88, no. 12, pp. 6672-89, 2014, ISSN: 1098-5514 (Electronic) 0022-538X (Linking).

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Bahraoui, E.; Briant, L.; Chazal, N.

E5564 inhibits immunosuppressive cytokine IL-10 induction promoted by HIV-1 Tat protein Journal Article

In: Virol J, vol. 11, pp. 214, 2014, ISSN: 1743-422X (Electronic) 1743-422X (Linking).

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Jabrane-Ferrat, N.; Siewiera, J.

The up side of decidual natural killer cells: new developments in immunology of pregnancy Journal Article

In: Immunology, vol. 141, no. 4, pp. 490-7, 2014, ISSN: 1365-2567 (Electronic) 0019-2805 (Linking).

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Lauden, L.; Siewiera, J.; Boukouaci, W.; Ramgolam, K.; Mourah, S.; Lebbe, C.; Charron, D.; Aoudjit, F.; Jabrane-Ferrat, N.; Al-Daccak, R.

TGF-beta-induced (TGFBI) protein in melanoma: a signature of high metastatic potential Journal Article

In: J Invest Dermatol, vol. 134, no. 6, pp. 1675-1685, 2014, ISSN: 1523-1747 (Electronic) 0022-202X (Linking).

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Boukouaci, W.; Lauden, L.; Siewiera, J.; Dam, N.; Hocine, H. R.; Khaznadar, Z.; Tamouza, R.; Borlado, L. R.; Charron, D.; Jabrane-Ferrat, N.; Al-Daccak, R.

Natural killer cell crosstalk with allogeneic human cardiac-derived stem/progenitor cells controls persistence Journal Article

In: Cardiovasc Res, vol. 104, no. 2, pp. 290-302, 2014, ISSN: 1755-3245 (Electronic) 0008-6363 (Linking).

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Social impact

Knowledge of the biology of RNA viruses and pathophysiological mechanisms.

Our research generates fundamental knowledge about chronic viral infections (HIV and HEV) and emerging infection (ZIKV), and clinical applications to combat these viruses whose pathophysiology remains unclear. Our links with the clinical departments of Toulouse University Hospital, with the technical platform of the CPTP and several international collaborations ensure the optimal development of original themes.

Teaching commitment

Our team members are committed to the teaching of students in the faculties of Medicine and Pharmacy; we also welcome Master and PhD students from both France and abroad to work and study in our laboratory.

Alumni

PhD students:

Maud Mavigner (2008-2011)
Nawal Benhaji (2009-2013)
Adrien Saliou (2010-2013)
Johan Siewiera (2010-2014)
Claire Loiseau (2012-2015)
Charline Daguzan (2012-2015)
Hugo Barragué (2015-2018)
Jordi Gouilly (2015-2018)
Manon Nayrac (2015-2019)
Nicolas Capelli (2016-2020)
Qian Chen (2016-2020)
Marie Armani (2017-2021)
Vincent Cantaloube-Ferrieu (2020-2023)
Claire Allioux (2021-2024)

Post Doctoral Fellow:

Sokunthea Top (2013-2014)
Romain Gasser (2016-2018)
Fanny Martini (2020-2022)
Philippe Colin (2018-2023

Partenaires Equipe 6

Sidaction

Sidaction

ANRS

ANRS

ATIP AVENIR

ATIP AVENIR

Hôpitaux de Toulouse

Hôpitaux de Toulouse

CNRS

CNRS